About: Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?
Creator	Aguilar-Castillo, M Arrabal-Gómez, C Cabezudo-García, P Ciano Petersen, N Estivill-Torrús, G Jiménez-Hernández, M Moya-Molina, M Oliver-Martos, B Reyes-Bueno, J Rodríguez De Fonseca, F Serrano-Castro, P Suárez-Pérez, J
Source	Elsevier; PMC
abstract	Abstract Introduction SARS-CoV-2 was first detected in December 2019 in the Chinese city of Wuhan and has since spread across the world. At present, the virus has infected over 1.7 million people and caused over 100000 deaths worldwide. Research is currently focused on understanding the acute infection and developing effective treatment strategies. In view of the magnitude of the epidemic, we conducted a speculative review of possible medium- and long-term neurological consequences of SARS-CoV-2 infection, with particular emphasis on neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin, based on the available evidence on neurological symptoms of acute SARS-CoV-2 infection. Development We systematically reviewed the available evidence about the pathogenic mechanisms of SARS-CoV-2 infection, the immediate and lasting effects of the cytokine storm on the central nervous system, and the consequences of neuroinflammation for the central nervous system. Conclusions SARS-CoV-2 is a neuroinvasive virus capable of triggering a cytokine storm, with persistent effects in specific populations. Although our hypothesis is highly speculative, the impact of SARS-CoV-2 infection on the onset and progression of neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin should be regarded as the potential cause of a delayed pandemic that may have a major public health impact in the medium to long term. Cognitive and neuropsychological function should be closely monitored in COVID-19 survivors.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.1016/j.nrleng.2020.04.002
has license	els-covid
sha1sum (hex)	6e3807c5839f56d3fcde255de8a9520e3c4c7e02
schema:url	https://doi.org/10.1016/j.nrleng.2020.04.002
resource representing a document's title	Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: A delayed pandemic?
has PubMed Central identifier	PMC7205729
resource representing a document's body	covid:6e3807c5839f56d3fcde255de8a9520e3c4c7e02#body_text
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