About: Antiviral Properties of R. tanguticum Nanoparticles on Herpes Simplex Virus Type I In Vitro and In Vivo

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral Properties of R. tanguticum Nanoparticles on Herpes Simplex Virus Type I In Vitro and In Vivo
Creator	Chen, Tian Hou, Wei Ma, Nian Wei, Fei Xiong, Hai-Rong Yang, Zhan-Qiu Liu, Dong-Ying Liu, Yuan-Yuan Li, Min-Ke Shen, Meng-Xin
Source	PMC
abstract	Herpes simplex virus type 1 (HSV-1), an enveloped DNA virus, plays a key role in varieties of diseases including recurrent cold sores, keratoconjunctivitis, genital herpes and encephalitis in humans. Great efforts have been made in developing more effective and less side-effects anti-herpes simplex virus agents, including traditional Chinese herbal medicines. In the present study, we evaluated the antiviral efficacy of Rheum tanguticum nanoparticles against HSV-1 in vitro and in vivo. R. tanguticum nanoparticles could inactivate the HSV-1 virions and block the viral attachment and entry into cells. Time-of-addition assay indicated that R. tanguticum nanoparticles could interfere with the entire phase of viral replication. Besides, R. tanguticum nanoparticles showed the ability to inhibit the mRNA expression of HSV-1 immediate early gene ICP4 and early gene ICP8 as well as the expression of viral protein ICP4 and ICP8. Moreover, R. tanguticum nanoparticles have been proved to protect mice against HSV-1 induced lethality by decreasing the viral load and alleviated pathological changes in brain tissues. In conclusion, we demonstrated that R. tanguticum nanoparticles could inhibit HSV-1 infection through multiple mechanisms. These results suggest that R. tanguticum nanoparticles may have novel roles in the treatment of HSV-1 infection.
has issue date	2019-09-04(xsd:dateTime)
bibo:doi	10.3389/fphar.2019.00959
bibo:pmid	31555137
has license	cc-by
sha1sum (hex)	6e2c37e888f6266374356b4dded392359a4695db
schema:url	https://doi.org/10.3389/fphar.2019.00959
resource representing a document's title	Antiviral Properties of R. tanguticum Nanoparticles on Herpes Simplex Virus Type I In Vitro and In Vivo
has PubMed Central identifier	PMC6737004
has PubMed identifier	31555137
schema:publication	Front Pharmacol
resource representing a document's body	covid:6e2c37e888f6266374356b4dded392359a4695db#body_text
is schema:about of	named entity 'ability' named entity 'antiviral' named entity 'gene' named entity 'cells' named entity 'MRNA EXPRESSION' named entity 'PATHOLOGICAL' named entity 'DECREASING' named entity 'DEMONSTRATED' named entity 'RHEUM TANGUTICUM' named entity 'ENTRY' named entity 'EFFECTIVE' named entity 'BRAIN TISSUES' named entity 'VIRAL PROTEIN' named entity 'IN VITRO' named entity 'INDUCED' named entity 'PHASE' named entity 'HAVE' named entity 'PROTEIN ' named entity 'HSV-1 INFECTION' named entity 'COLD SORES' named entity 'THESE' named entity 'STUDY' named entity 'VIRAL REPLICATION' named entity 'EFFECTS' named entity 'ROLES' named entity 'ROLE' named entity 'VIRAL ATTACHMENT' named entity 'CONCLUSION' named entity 'KERATOCONJUNCTIVITIS' named entity 'KEY' named entity 'MULTIPLE' named entity 'LETHALITY' named entity 'EVALUATED' named entity 'GREAT' named entity 'RECURRENT' named entity 'MECHANISMS' named entity 'INDICATED' named entity 'ANTIVIRAL' named entity 'EFFICACY' named entity 'RESULTS' named entity 'ARTICLE' named entity 'SUGGEST' named entity 'TO INHIBIT' named entity 'DNA VIRUS' named entity 'BLOCK' named entity 'CELLS' named entity 'DISEASES' named entity 'ASSAY' named entity 'DEVELOPING' named entity 'ORIGINAL' named entity 'EARLY GENE' named entity 'RESEARCH' named entity 'HUMANS' named entity 'NANOPARTICLES' named entity 'INCLUDING' named entity 'HERPES SIMPLEX VIRUS TYPE 1' named entity 'INTERFERE' named entity 'EXPRESSION' named entity 'NOVEL' named entity 'TREATMENT' named entity 'HSV-1' named entity 'PRESENT' named entity 'PLAYS' named entity 'GENITAL HERPES' named entity 'ENTIRE' named entity 'MAY HAVE' named entity 'ANTI-HERPES SIMPLEX VIRUS AGENTS' named entity 'TIME' named entity 'IN VIVO' named entity 'TRADITIONAL' named entity 'CHANGES' named entity 'IMMEDIATE EARLY GENE'

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