About: Quantity and Size Distribution of Cough-Generated Aerosol Particles Produced by Influenza Patients During and After Illness

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Quantity and Size Distribution of Cough-Generated Aerosol Particles Produced by Influenza Patients During and After Illness
Creator	Beezhold, Donald Blachere, Francoise Lindsley, William Clark, Karen Celik, Ismail Coffey, Christopher Davis, Kristina Davis, Stephen Fisher, Melanie Hudnall, Judith Khakoo, Rashida Palmer, Jan Pearce, Terri
topic	covid:6d4ffd03fd04098c0abd879073e4bf7cfff7834f#this
Source	PMC
abstract	The question of whether influenza is transmitted to a significant degree by aerosols remains controversial, in part, because little is known about the quantity and size of potentially infectious airborne particles produced by people with influenza. In this study, the size and amount of aerosol particles produced by nine subjects during coughing were measured while they had influenza and after they had recovered, using a laser aerosol particle spectrometer with a size range of 0.35 to 10 μm. Individuals with influenza produce a significantly greater volume of aerosol when ill compared with afterward (p = 0.0143). When the patients had influenza, their average cough aerosol volume was 38.3 picoliters (pL) of particles per cough (SD 43.7); after patients recovered, the average volume was 26.4 pL per cough (SD 45.6). The number of particles produced per cough was also higher when subjects had influenza (average 75,400 particles/cough, SD 97,300) compared with afterward (average 52,200, SD 98,600), although the difference did not reach statistical significance (p = 0.1042). The average number of particles expelled per cough varied widely from patient to patient, ranging from 900 to 302,200 particles/cough while subjects had influenza and 1100 to 308,600 particles/cough after recovery. When the subjects had influenza, an average of 63% of each subject's cough aerosol particle volume in the detection range was in the respirable size fraction (SD 22%), indicating that these particles could reach the alveolar region of the lungs if inhaled by another person. This enhancement in aerosol generation during illness may play an important role in influenza transmission and suggests that a better understanding of this phenomenon is needed to predict the production and dissemination of influenza-laden aerosols by people infected with this virus. [Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resources: a PDF file of demographic information, influenza test results, and volume and peak flow rate during each cough and a PDF file containing number and size of aerosol particles produced.]
has issue date	2012-05-31(xsd:dateTime)
bibo:doi	10.1080/15459624.2012.684582
bibo:pmid	22651099
has license	no-cc
sha1sum (hex)	6d4ffd03fd04098c0abd879073e4bf7cfff7834f
schema:url	https://doi.org/10.1080/15459624.2012.684582
resource representing a document's title	Quantity and Size Distribution of Cough-Generated Aerosol Particles Produced by Influenza Patients During and After Illness
has PubMed Central identifier	PMC4676262
has PubMed identifier	22651099
schema:publication	J Occup Environ Hyg
resource representing a document's body	covid:6d4ffd03fd04098c0abd879073e4bf7cfff7834f#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/6d4ffd03fd04098c0abd879073e4bf7cfff7834f
is schema:about of	named entity 'Influenza' named entity 'Quantity' named entity 'Aerosol Particles' named entity 'standard deviation' named entity 'influenza' named entity 'aerosol' named entity 'SD 45' named entity 'aerosol' named entity 'aerosol' named entity 'cough' named entity 'peak flow rate' named entity 'general health' named entity 'cough' named entity 'lungs' named entity 'disinfectant' named entity 'public health' named entity 'statistically significant' named entity 'potentially infectious' named entity 'airway' named entity 'aerosol' named entity 'coughing' named entity 'upper limit' named entity 'alveolar region' named entity 'rhinovirus' named entity 'coughing' named entity 'NIOSH' named entity 'airborne particles' named entity 'ultrasonic' named entity 'influenza' named entity 'influenza' named entity 'particle size' named entity 't-test' named entity 'influenza transmission' named entity 'VMD' named entity 'Aerosol particles' named entity 'infectious dose' named entity 'airborne transmission' named entity 'influenza' named entity 'cough' named entity 'laser' named entity 'influenza' named entity 'influenza' named entity 'aerosols' named entity 'aerosols' named entity 'cough' named entity 'influenza' named entity 'aerosol' named entity 'aerodynamic diameter' named entity 'Calif.' named entity 'respirable' named entity 'aerosols' named entity 'cough' named entity 'cough' named entity 'aerosol' named entity 'aerosol' named entity 'National Institute for Occupational Safety and Health' named entity 'particle size distribution' named entity 'influenza' named entity 'emergency department' named entity 'cough' named entity 'World Health Organization' named entity 'cough' named entity 'aerodynamic diameter' named entity 'rapid influenza test' named entity 'PCR' named entity 'particle size' named entity 'ACGIH'

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