About: Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis

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About: Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis
Creator	Suzuki, Satoshi Ikeda, Mayu Imai, Kazuo Ito, Toshimitsu Kawano, Shuichi Kitagaki, Manabu Kodama, Tatsuya Kodera, Tsutomu Mimura, Satoshi Miyoshi, Kazuyasu Obinata, Hirofumi Sato, Michiya Tabata, Sakiko Tamura, Kaku Uwabe, Yasuhide
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: The ongoing COVID-19 pandemic is a global threat. Identification of markers for symptom onset and disease progression is a pressing issue. We described the clinical features of people infected on board the Diamond Princess cruise ship who were diagnosed with asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or mild or severe COVID-19, on admission to the Self-Defense Forces Central Hospital (Tokyo, Japan) and at the end of observation. METHODS: This retrospective, single-centre study included participants with laboratory-detected SARS-CoV-2 infection who were admitted to the Self-Defense Forces Central Hospital from Feb 11 to Feb 25, 2020. Clinical records, laboratory data, and radiological findings were analysed. Clinical outcomes were followed up until discharge or Feb 26, 2020, whichever came first. We defined asymptomatic infection as SARS-CoV-2 infection with no history of clinical signs and symptoms, severe COVID-19 as clinical symptoms of pneumonia (dyspnoea, tachypnoea, peripheral capillary oxygen saturation <93%, and need for oxygen therapy), and mild COVID-19 as all other symptoms. Clinical features on admission were compared among patients with different disease severity, including asymptomatic infection, at the end of observation. We used univariable analysis to identify factors associated with symptomatic illness among asymptomatic people infected with SARS-CoV-2 and disease progression in patients with COVID-19. FINDINGS: Among the 104 participants included in the final analysis, the median age was 68 years (IQR 47–75) and 54 (52%) were male. On admission, 43 (41%) participants were classified as asymptomatic, 41 (39%) as having mild COVID-10, and 20 (19%) as having severe COVID-19. At the end of observation, 33 (32%) participants were confirmed as being asymptomatic, 43 (41%) as having mild COVID-19, and 28 (27%) as having severe COVID-19. Serum lactate hydrogenase concentrations were significantly higher in the ten participants who were asymptomatic on admission but developed symptomatic COVID-19 compared with the 33 participants who remained asymptomatic throughout the observation period (five [50%] vs four [12%] participants; odds ratio 7·25, 95% CI 1·43–36·70; p=0·020). Compared with patients with mild disease at the end of observation, patients with severe COVID-19 were older (median age 73 years [IQR 55–77] vs 60 years [40–71]; p=0·028) and had more frequent consolidation on chest CT (13 [46%] of 28 vs nine [21%] of 43; p=0·035) and lymphopenia (16 [57%] vs ten [23%]; p=0·0055) on admission. INTERPRETATION: Older age, consolidation on chest CT images, and lymphopenia might be risk factors for disease progression of COVID-19 and contribute to improved clinical management. FUNDING: None.
has issue date	2020-06-12(xsd:dateTime)
bibo:doi	10.1016/s1473-3099(20)30482-5
bibo:pmid	32539988
has license	no-cc
sha1sum (hex)	6d4b3bfbc8e4c2ab4505c4e9d709625ae7b96fe4
schema:url	https://doi.org/10.1016/s1473-3099%2820%2930482-5
resource representing a document's title	Clinical characteristics of COVID-19 in 104 people with SARS-CoV-2 infection on the Diamond Princess cruise ship: a retrospective analysis
has PubMed Central identifier	PMC7292609
has PubMed identifier	32539988
schema:publication	Lancet Infect Dis
resource representing a document's body	covid:6d4b3bfbc8e4c2ab4505c4e9d709625ae7b96fe4#body_text
is schema:about of	named entity 'symptom' named entity 'COVID-19' named entity 'CENTRAL' named entity 'DIAMOND' named entity 'global' named entity 'Tokyo' named entity 'severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)' named entity 'cruise ship' named entity 'infected' named entity 'Diamond Princess' named entity 'Japan' named entity 'Central Hospital' named entity 'infection' named entity 'SARS-CoV-2' named entity 'asymptomatic' named entity 'COVID-19' named entity 'Princess cruise ship' named entity 'SARS-CoV-2' named entity 'WHO' named entity 'COVID' named entity 'chest CT' named entity 'COVID' named entity 'final analysis' named entity 'RT-PCR' named entity 'infection' named entity 'COVID' named entity 'risk factors' named entity 'pneumonia' named entity 'COVID' named entity 'lymphopenia' named entity 'COVID' named entity 'physical examinations' named entity 'lung' named entity 'lung tissue' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'asymptomatic' named entity 'clinical symptoms' named entity 'asymptomatic' named entity 'SARS-CoV-2' named entity 'Diamond Princess' named entity 'COVID' named entity 'serum' named entity 'bronchiectasis' named entity 'asymptomatic infection' named entity 'comorbidities' named entity 'asymptomatic' named entity 'pneumonia' named entity 'SARS-CoV-2' named entity 'older age' named entity 'Student's t test' named entity 'pneumonia' named entity 'funding source' named entity 'Diamond Princess' named entity 'SARS-CoV-2' named entity 'symptom' named entity 'oxygen saturation' named entity 'asymptomatic' named entity 'Stata' named entity 'asymptomatic' named entity 'SARS-CoV-2' named entity 'radiographical' named entity 'Informed consent' named entity 'symptom' named entity 'medical records' named entity 'Diamond Princess cruise ship' named entity 'infectious diseases' named entity 'risk factors'

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