About: Nanomaterial assisted bulk scale synthesis of 2-methyl-6-nitroquinoline

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Nanomaterial assisted bulk scale synthesis of 2-methyl-6-nitroquinoline
Creator	Chandrappa, M Girish Kumar, S Kumar Pullela, Phani Swathi, Korrapati
Source	Elsevier; Medline; PMC
abstract	Quinolines are an interesting class of moieties with various medicinal chemistry uses. The most prominent is their ability to be used as the last line of therapy for bacterial and viral infections including recent COVID-19. The synthesis of quinoline is through a cyclization reaction and overall reaction yields are about 20%. The bulky ring and the associated crowding of functional groups limit the catalyst options. In this publication, the use of Fe(3)O(4)@SiO(2) for enhancing yield improvements, especially for heterocyclics is reported. The use of the 40 nm sized silica functionalized magnetite nanoparticles seems to help in both condensation and cyclization steps of representative 2-methyl-6-nitroquinoline. Reaction time reduction due to surface enabled catalysis of nanoparticles is 110 min to 80 min. The reaction yield has doubled due to the presence of catalyst and the mechanism suggests this drastic result is due to stabilization of unstable intermediate on the acidic surface of the silica coating. This near homogeneous catalysis of 40 nm sized, silica functionalized, magnetite nanoparticles have far reaching applications in bulk drug industry for drugs like chloroquine & hydroxychloroquine, the two essential drugs for prophylactic use for COVID-1.
has issue date	2020-08-09(xsd:dateTime)
bibo:doi	10.1016/j.matpr.2020.07.103
bibo:pmid	32837922
has license	no-cc
sha1sum (hex)	6ce15a4558189ff0c7e18564848a8f16b41b38d9
schema:url	https://doi.org/10.1016/j.matpr.2020.07.103
resource representing a document's title	Nanomaterial assisted bulk scale synthesis of 2-methyl-6-nitroquinoline
has PubMed Central identifier	PMC7415172
has PubMed identifier	32837922
schema:publication	Mater Today Proc
resource representing a document's body	covid:6ce15a4558189ff0c7e18564848a8f16b41b38d9#body_text
is schema:about of	named entity 'Reaction time' named entity 'improvements' named entity 'COVID-19' named entity 'cyclization' named entity 'result' named entity 'ENABLED' named entity 'LINE OF THERAPY' named entity 'BULK' named entity 'sized' named entity 'functionalized' named entity 'yield' named entity 'silica' named entity 'methyl' named entity 'sized' named entity 'catalyst' named entity 'magnetite' named entity 'ring' named entity 'enabled' named entity 'bacterial' named entity 'heterocyclics' named entity 'silica' named entity 'prominent' named entity 'representative' named entity 'quinoline' named entity 'yields' named entity 'heterocyclics' named entity 'functional groups' named entity 'cyclization reaction' named entity 'quinoline' named entity 'drug industry' named entity 'essential drugs' named entity 'condensation' named entity 'methyl' named entity 'nanoparticles' named entity 'nanoparticles' named entity 'magnetite' named entity 'prophylactic' named entity 'nanoparticles' named entity 'Nanomaterial' named entity 'extensively drug resistant' named entity 'organic synthesis' named entity 'Quinolines' named entity 'methyl' named entity 'trisodium citrate' named entity 'TEOS' named entity 'aromatization' named entity 'heterogeneous catalyst' named entity 'aromatic amine' named entity 'Lewis acids' named entity 'quinoline' named entity 'process chemistry' named entity 'antimalarials' named entity 'Michael addition' named entity 'distilled water' named entity 'nanomaterials' named entity 'aldehyde' named entity 'reaction yields' named entity 'reaction time' named entity 'room temperature' named entity 'Quinolines' named entity 'reflux' named entity 'process chemistry' named entity 'silica' named entity 'zeolites' named entity 'non-specific' named entity '4-nitroaniline' named entity 'sodium hydroxide' named entity 'distilled water' named entity 'solvent' named entity 'methyl' named entity 'neutral alumina' named entity 'reaction yield' named entity 'SEM' named entity 'chloroquine' named entity 'condensation' named entity 'tuberculosis' named entity 'peer-review' named entity 'sonicated'

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