About: Molecular Epidemiology of Human Rhinoviruses and Enteroviruses Highlights Their Diversity in Sub-Saharan Africa

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About: Molecular Epidemiology of Human Rhinoviruses and Enteroviruses Highlights Their Diversity in Sub-Saharan Africa Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular Epidemiology of Human Rhinoviruses and Enteroviruses Highlights Their Diversity in Sub-Saharan Africa
Creator	Kaiser, Laurent Tapparel, Caroline Turin, Lara Genton, Blaise Kilowoko, Mary Kyungu, Esther Belov, George D'acremont, Valérie Hongoa, Philipina L'huillier, Arnaud Petty, Tom Vieille, Gaël
Source	PMC
abstract	Human rhinoviruses (HRVs) and enteroviruses (HEVs) belong to the Enterovirus genus and are the most frequent cause of infection worldwide, but data on their molecular epidemiology in Africa are scarce. To understand HRV and HEV molecular epidemiology in this setting, we enrolled febrile pediatric patients participating in a large prospective cohort assessing the causes of fever in Tanzanian children. Naso/oropharyngeal swabs were systematically collected and tested by real-time RT-PCR for HRV and HEV. Viruses from positive samples were sequenced and phylogenetic analyses were then applied to highlight the HRV and HEV types as well as recombinant or divergent strains. Thirty-eight percent (378/1005) of the enrolled children harboured an HRV or HEV infection. Although some types were predominant, many distinct types were co-circulating, including a vaccinal poliovirus, HEV-A71 and HEV-D68. Three HRV-A recombinants were identified: HRV-A36/HRV-A67, HRV-A12/HRV-A67 and HRV-A96/HRV-A61. Four divergent HRV strains were also identified: one HRV-B strain and three HRV-C strains. This is the first prospective study focused on HRV and HEV molecular epidemiology in sub-Saharan Africa. This systematic and thorough large screening with careful clinical data management confirms the wide genomic diversity of these viruses, brings new insights about their evolution and provides data about associated symptoms.
has issue date	2015-12-08(xsd:dateTime)
bibo:doi	10.3390/v7122948
bibo:pmid	26670243
has license	cc-by
sha1sum (hex)	6c9ce983d25f6c0727c9e4fedc01e84b046673a4
schema:url	https://doi.org/10.3390/v7122948
resource representing a document's title	Molecular Epidemiology of Human Rhinoviruses and Enteroviruses Highlights Their Diversity in Sub-Saharan Africa
has PubMed Central identifier	PMC4690871
has PubMed identifier	26670243
schema:publication	Viruses
resource representing a document's body	covid:6c9ce983d25f6c0727c9e4fedc01e84b046673a4#body_text
is schema:about of	named entity 'Enterovirus' named entity 'Africa' named entity 'evolution' named entity 'systematic' named entity 'ENTEROVIRUSES' named entity 'REAL-TIME RT-PCR' named entity 'RHINOVIRUSES' named entity 'D68' named entity 'DIVERSITY' named entity 'HUMAN' named entity 'FEBRILE' named entity 'IDENTIFIED' named entity 'A71' named entity 'PREDOMINANT' named entity 'APPLIED' named entity 'CONFIRMS' named entity 'WORLDWIDE' named entity 'PROVIDES' named entity 'A12' named entity 'THEIR' named entity 'RHINOVIRUSES' named entity 'ENROLLED' named entity 'CHILDREN' named entity 'SCREENING' named entity 'DATA' named entity 'THIRTY' named entity 'COLLECTED' named entity 'INCLUDING' named entity 'GENOMIC' named entity 'MOLECULAR EPIDEMIOLOGY' named entity 'SUB-SAHARAN AFRICA' named entity 'INSIGHTS' named entity 'LARGE' named entity 'DIVERSITY' named entity 'POSITIVE' named entity 'DISTINCT' named entity 'MOLECULAR EPIDEMIOLOGY' named entity 'FREQUENT' named entity 'PROSPECTIVE COHORT' named entity '28378' named entity 'A67' named entity 'WIDE' named entity 'POLIOVIRUS' named entity 'ASSESSING' named entity 'ABOUT' named entity 'FEVER' named entity 'CIRCULATING' named entity 'DATA MANAGEMENT' named entity 'HUMAN' named entity 'SETTING' named entity 'HRV' named entity 'HEV' named entity 'TANZANIAN' named entity 'SWABS' named entity 'CAUSES' named entity 'RECOMBINANT' named entity 'PARTICIPATING' named entity 'CLINICAL DATA' named entity 'A36' named entity 'PATIENTS' named entity 'GENUS' named entity 'EVOLUTION' named entity 'CAUSE' named entity 'NEW' named entity 'PERCENT' named entity 'TESTED' named entity 'HRV-A' named entity 'FOCUSED' named entity 'RECOMBINANTS' named entity 'TYPES'

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