About: Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease
Creator	Diesch, Jeannine Sanij, Elaine Hannan, Ross
Source	PMC
abstract	Ribosomal RNA (rRNA) gene (rDNA) transcription by RNA Polymerase I (Pol I) drives cell growth and underlies nucleolar structure and function, indirectly coordinating many fundamental cellular processes. The importance of keeping rDNA transcription under tight control is reflected by the fact that deranged Pol I transcription is a feature of cancer and other human disorders. In this review, we discuss multiple aspects of rDNA function including the relationship between Pol I transcription and proliferative capacity, the role of Pol I transcription in mediating nucleolar structure and integrity, and rDNA/nucleolar interactions with the genome and their influence on heterochromatin and global genome stability. Furthermore, we discuss how perturbations in the structure of the rDNA loci might contribute to human disease, in some cases independent of effects on ribosome biogenesis.
has issue date	2014-08-19(xsd:dateTime)
bibo:doi	10.1186/2045-3701-4-43
bibo:pmid	25949792
has license	cc-by
sha1sum (hex)	6bfa66e7befc8ca735ef61dc392a32d1c56ea01e
schema:url	https://doi.org/10.1186/2045-3701-4-43
resource representing a document's title	Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease
has PubMed Central identifier	PMC4422213
has PubMed identifier	25949792
schema:publication	Cell Biosci
resource representing a document's body	covid:6bfa66e7befc8ca735ef61dc392a32d1c56ea01e#body_text
is schema:about of	named entity 'CELLULAR PROCESSES' named entity 'LOCI' named entity 'FACT' named entity 'CONTROL' named entity 'THEIR' named entity 'HETEROCHROMATIN' named entity 'RIBOSOME BIOGENESIS' named entity 'GENE' named entity 'DYSFUNCTION' named entity 'feature' named entity 'function' named entity 'Pol I' named entity 'fundamental' named entity 'transcription' named entity 'cellular' named entity 'centre' named entity 'HUMAN' named entity 'INTERACTIONS' named entity 'INFLUENCE' named entity 'MEDIATING' named entity 'CAPACITY' named entity 'EFFECTS' named entity 'PROLIFERATIVE' named entity 'CONTRIBUTE ' named entity 'CANCER' named entity 'CELL GROWTH' named entity 'GLOBAL' named entity 'RDNA' named entity 'MULTIPLE' named entity 'STRUCTURE' named entity 'FUNCTION' named entity 'DRIVES' named entity 'REVIEW' named entity 'RELATIONSHIP' named entity 'TRANSCRIPTION' named entity 'HUMAN DISEASE' named entity 'RIBOSOMAL GENES' named entity 'COORDINATING' named entity 'HUMAN DISEASE' named entity 'POL I' named entity 'RIBOSOMAL RNA' named entity 'DISCUSS' named entity 'FEATURE' named entity 'DISORDERS' named entity 'LOCI' named entity 'CELLULAR' named entity 'CENTRE' named entity 'GENOME' named entity 'TIGHT' named entity 'HOW' named entity 'TRANSCRIPTION BY RNA POLYMERASE I' named entity 'ROLE' named entity 'INCLUDING' named entity 'INTEGRITY' named entity 'NUCLEOLAR' named entity 'INDEPENDENT OF' named entity 'STABILITY' named entity 'IS A' named entity 'REFLECTED' named entity 'CASES' named entity 'fact' named entity 'structure' named entity 'rDNA' named entity 'Ribosomal RNA' named entity 'perturbations' named entity 'stability' named entity 'global' named entity 'rDNA' named entity 'cellular processes' named entity 'Pol I' named entity 'drives' named entity 'loci' named entity 'transcription' named entity 'ribosome biogenesis' named entity 'human disease' named entity 'Smc5' named entity 'nucleophosmin' named entity 'gene expression' named entity 'chromosome territories'

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