About: Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review
Creator	Simpson, Julie Fowkes, Freya Agius, Paul Cutts, Julia Draper, Bridget Lin, Zaw Moore, Kerryn Powell, Rosanna
Source	PMC
abstract	BACKGROUND: In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumulation of parasitized red blood cells (pRBC) in the placenta. In subsequent pregnancies, women develop protective immunity to pregnancy-associated malaria and this has been hypothesized to be due to the acquisition of antibodies to the parasite variant surface antigen VAR2CSA. In this systematic review we provide the first synthesis of the association between antibodies to pregnancy-specific P. falciparum antigens and pregnancy and birth outcomes. METHODS: We conducted a systematic review and meta-analysis of population-based studies (published up to 07 June 2019) of pregnant women living in P. falciparum endemic areas that examined antibody responses to pregnancy-specific P. falciparum antigens and outcomes including placental malaria, low birthweight, preterm birth, peripheral parasitaemia, maternal anaemia, and severe malaria. RESULTS: We searched 6 databases and identified 33 studies (30 from Africa) that met predetermined inclusion and quality criteria: 16 studies contributed estimates in a format enabling inclusion in meta-analysis and 17 were included in narrative form only. Estimates were mostly from cross-sectional data (10 studies) and were heterogeneous in terms of magnitude and direction of effect. Included studies varied in terms of antigens tested, methodology used to measure antibody responses, and epidemiological setting. Antibody responses to pregnancy-specific pRBC and VAR2CSA antigens, measured at delivery, were associated with placental malaria (9 studies) and may therefore represent markers of infection, rather than correlates of protection. Antibody responses to pregnancy-specific pRBC, but not recombinant VAR2CSA antigens, were associated with trends towards protection from low birthweight (5 studies). CONCLUSIONS: Whilst antibody responses to several antigens were positively associated with the presence of placental and peripheral infections, this review did not identify evidence that any specific antibody response is associated with protection from pregnancy-associated malaria across multiple populations. Further prospective cohort studies using standardized laboratory methods to examine responses to a broad range of antigens in different epidemiological settings and throughout the gestational period, will be necessary to identify and prioritize pregnancy-specific P. falciparum antigens to advance the development of vaccines and serosurveillance tools targeting pregnant women.
has issue date	2020-01-16(xsd:dateTime)
bibo:doi	10.1186/s12916-019-1467-6
bibo:pmid	31941488
has license	cc-by
sha1sum (hex)	6b74cc91c3e2b694dbf4a0e21226f8abde478409
schema:url	https://doi.org/10.1186/s12916-019-1467-6
resource representing a document's title	Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review
has PubMed Central identifier	PMC6964062
has PubMed identifier	31941488
schema:publication	BMC Med
resource representing a document's body	covid:6b74cc91c3e2b694dbf4a0e21226f8abde478409#body_text
is schema:about of	named entity 'settings' named entity 'correlates' named entity 'peripheral' named entity 'laboratory' named entity 'responses' named entity 'provide' named entity 'epidemiological' named entity 'living' named entity 'pRBC' named entity 'predetermined' named entity 'tools' named entity 'META-ANALYSIS' named entity 'METHODS' named entity 'REPRESENT' named entity 'TOOLS' named entity 'EFFECT' named entity 'LIVING' named entity 'PREDETERMINED' named entity 'TO MEASURE' named entity 'EPIDEMIOLOGICAL' named entity 'USING' named entity 'ANTIBODIES' named entity 'MET' named entity 'ASSOCIATION' named entity 'AFRICA' named entity 'FORM' named entity 'PLACENTA' named entity 'DUE TO' named entity 'SUSCEPTIBLE' named entity 'CHARACTERIZED' named entity 'LOW BIRTHWEIGHT' named entity 'DATABASES' named entity 'UP TO' named entity 'SEARCHED' named entity 'TO EXAMINE' named entity 'SPECIFIC ANTIBODY' named entity 'RESPONSES' named entity 'TERMS' named entity 'subsequent' named entity 'antigen' named entity 'presence' named entity 'meta-analysis' named entity 'pregnancy' named entity 'malaria' named entity 'specific' named entity 'immunity' named entity 'birthweight' named entity 'P. falciparum' named entity 'placental' named entity 'highly' named entity 'epidemiological' named entity 'gestational period' named entity 'inclusion' named entity 'pregnancy-associated malaria' named entity 'pRBC' named entity 'Antibody' named entity 'P. falciparum' named entity 'anaemia' named entity 'endemic' named entity 'placental' named entity 'antigens' named entity 'correlates of protection' named entity 'meta-analysis' named entity 'vaccines' named entity 'red blood cells' named entity 'placenta' named entity 'parasite' named entity 'P. falciparum' named entity 'antigens' named entity 'antibody' named entity 'antibody' named entity 'infection' named entity 'prospective cohort studies' named entity 'pregnancy-associated malaria'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software