About: Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study

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About: Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study
Creator	Robert, René Al-Salameh, Abdallah Allix, Ingrid Amadou, Coralie Arnault, Gwénaëlle Baudoux, Florence Bauduceau, Bernard Cariou, Bertrand Hadjadj, Samy Kerlan, Véronique Laviolle, Bruno Marchand, Lucien Meyer, Laurent Pichelin, Matthieu Potier, Louis Prevost, Gaëtan Riveline, Jean-Pierre Saulnier, Pierre-Jean Sultan, Ariane Wargny, Matthieu
Source	Medline; PMC
abstract	AIMS/HYPOTHESIS: Coronavirus disease-2019 (COVID-19) is a life-threatening infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Diabetes has rapidly emerged as a major comorbidity for COVID-19 severity. However, the phenotypic characteristics of diabetes in COVID-19 patients are unknown. METHODS: We conducted a nationwide multicentre observational study in people with diabetes hospitalised for COVID-19 in 53 French centres in the period 10–31 March 2020. The primary outcome combined tracheal intubation for mechanical ventilation and/or death within 7 days of admission. Age- and sex-adjusted multivariable logistic regressions were performed to assess the prognostic value of clinical and biological features with the endpoint. ORs are reported for a 1 SD increase after standardisation. RESULTS: The current analysis focused on 1317 participants: 64.9% men, mean age 69.8 ± 13.0 years, median BMI 28.4 (25th–75th percentile: 25.0–32.7) kg/m(2); with a predominance of type 2 diabetes (88.5%). Microvascular and macrovascular diabetic complications were found in 46.8% and 40.8% of cases, respectively. The primary outcome was encountered in 29.0% (95% CI 26.6, 31.5) of participants, while 10.6% (9.0, 12.4) died and 18.0% (16.0, 20.2) were discharged on day 7. In univariate analysis, characteristics prior to admission significantly associated with the primary outcome were sex, BMI and previous treatment with renin–angiotensin–aldosterone system (RAAS) blockers, but not age, type of diabetes, HbA(1c), diabetic complications or glucose-lowering therapies. In multivariable analyses with covariates prior to admission, only BMI remained positively associated with the primary outcome (OR 1.28 [1.10, 1.47]). On admission, dyspnoea (OR 2.10 [1.31, 3.35]), as well as lymphocyte count (OR 0.67 [0.50, 0.88]), C-reactive protein (OR 1.93 [1.43, 2.59]) and AST (OR 2.23 [1.70, 2.93]) levels were independent predictors of the primary outcome. Finally, age (OR 2.48 [1.74, 3.53]), treated obstructive sleep apnoea (OR 2.80 [1.46, 5.38]), and microvascular (OR 2.14 [1.16, 3.94]) and macrovascular complications (OR 2.54 [1.44, 4.50]) were independently associated with the risk of death on day 7. CONCLUSIONS/INTERPRETATIONS: In people with diabetes hospitalised for COVID-19, BMI, but not long-term glucose control, was positively and independently associated with tracheal intubation and/or death within 7 days. TRIAL REGISTRATION: clinicaltrials.gov NCT04324736. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-020-05180-x) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
has issue date	2020-05-29(xsd:dateTime)
bibo:doi	10.1007/s00125-020-05180-x
bibo:pmid	32472191
has license	cc-by
sha1sum (hex)	6b6471be54fa0da250a423de8f4c9674c730ca8a
schema:url	https://doi.org/10.1007/s00125-020-05180-x
resource representing a document's title	Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study
has PubMed Central identifier	PMC7256180
has PubMed identifier	32472191
schema:publication	Diabetologia
resource representing a document's body	covid:6b6471be54fa0da250a423de8f4c9674c730ca8a#body_text
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