About: Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination

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About: Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination
Creator	Das Sarma, Jayasri Biswas, Kaushiki Chatterjee, Dhriti Addya, Sankar Choe, Alexander Cohrs, Randall Kenyon, Lawrence Khan, Reas Shindler, Kenneth
Source	Elsevier; Medline; PMC
abstract	The presence of immunoglobulin oligoclonal bands in the cerebrospinal fluid of Multiple Sclerosis (MS) patients supports the hypothesis of an infectious etiology, although the antigenic targets remain elusive. Neurotropic mouse hepatitis virus (MHV) infection in mice provides a useful tool for studying mechanisms of demyelination in a virus-induced experimental model of MS. This study uses Affymetrix microarray analysis to compare differential spinal cord mRNA levels between mice infected with demyelinating and non-demyelinating strains of MHV to identify host immune genes expressed in this demyelinating disease model. The study reveals that during the acute stage of infection, both strains induce inflammatory innate immune response genes, whereas upregulation of several immunoglobulin genes during chronic stage infection is unique to infection with the demyelinating strain. Results suggest that the demyelinating strain induced an innate-immune response during acute infection that may promote switching of Ig isotype genes during chronic infection, potentially playing a role in antibody-mediated progressive demyelination even after viral clearance.
has issue date	2016-07-06(xsd:dateTime)
bibo:doi	10.1016/j.clim.2016.07.004
bibo:pmid	27394164
has license	no-cc
sha1sum (hex)	6b237e0054b0120b98182f96deae4c4fdd3dbde4
schema:url	https://doi.org/10.1016/j.clim.2016.07.004
resource representing a document's title	Demyelinating strain of mouse hepatitis virus infection bridging innate and adaptive immune response in the induction of demyelination
has PubMed Central identifier	PMC7106046
has PubMed identifier	27394164
schema:publication	Clin Immunol
resource representing a document's body	covid:6b237e0054b0120b98182f96deae4c4fdd3dbde4#body_text
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