About: Clones of cells from a human embryo lung: Their growth and susceptibility to respiratory viruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clones of cells from a human embryo lung: Their growth and susceptibility to respiratory viruses
Creator	Ci~appi~e, P Jones, W Mika-Joh~so~, Marcia Tyt~rell, D
Source	Medline; PMC
abstract	Colonies of cells were obtained from human fetal lung tissue and exposed to recently isolated respiratory viruses. There was a considerable variation in the number of rounded cells found in different colonies exposed to rhinovirus types 2 and 9 (RV2 and 9), human coronavirus 229 E (HCV), adenovirus type 3 (Ad3) and respiratory syncytial virus (RSV). Smaller colonies had more rounded cells than larger colonies. Clones were established from 9 out of 11 colonies. They varied in their rate of growth and the pattern formed on a plastic surface. They varied also in their virus susceptibility particularly to “difficult” rhinoviruses such as RV9 and SF 1340. One cell clone (HL1/77 Clone 8), was highly susceptible to all these viruses. All cultures were more sensitive to RSV when maintained in F 12K medium than in MEM, whereas there was no difference for rhinoviruses. Influenza A and B and parainfluenza 3 viruses sometimes produced cytopathic effect, and always produced haemadsorption, but unlike the previous strains could not be passed serially and presumably produced little infections virus. All clones were rather insusceptible to Ad3; but the virus could be passed, whereas coxsackie virus B3 produced no CPE. Substantial yields of coronavirus and rhinovirus were obtained in gelatin sponge cultures. Two “very difficult” respiratory viruses which had just been adapted to tissue culture; namely, HS rhinovirus and JK coronavirus grew in 7 of 9 and in 6 of 9 clones respectively.
has issue date	1979-01-01(xsd:dateTime)
bibo:doi	10.1007/bf01320593
bibo:pmid	229795
has license	no-cc
sha1sum (hex)	6b18d72e0ecdd840251f81ba211de397837a63be
schema:url	https://doi.org/10.1007/bf01320593
resource representing a document's title	Clones of cells from a human embryo lung: Their growth and susceptibility to respiratory viruses
has PubMed Central identifier	PMC7086877
has PubMed identifier	229795
schema:publication	Arch Virol
resource representing a document's body	covid:6b18d72e0ecdd840251f81ba211de397837a63be#body_text
is schema:about of	named entity 'Lung' named entity 'Respiratory' named entity 'Human' named entity 'Clones' named entity 'CLONES' named entity 'VIROLOGY' named entity 'GROWTH' named entity 'THEIR' named entity 'LUNG' named entity 'SUSCEPTIBILITY' named entity 'ARCHIVES' named entity 'CELLS' named entity 'HUMAN EMBRYO' named entity 'RESPIRATORY VIRUSES' named entity 'Lung' named entity 'Human Embryo' named entity 'epithelial cells' named entity 'clones' named entity 'vaccines' named entity 'gelatin sponge' named entity 'culture medium' named entity 'clone' named entity 'biochemistry' named entity 'clones' named entity 'diploid' named entity 'virus' named entity 'parainfluenza' named entity 'cloning' named entity 'coronaviruses' named entity 'cell cloning' named entity 'parainfluenza virus' named entity 'lung' named entity 'virus' named entity 'fibroblasts' named entity 'virus' named entity 'cloning' named entity 'phase contrast' named entity 'influenza' named entity 'rhinovirus' named entity 'organ' named entity 'Human embryonic' named entity 'cell suspension' named entity 'organ culture' named entity 'embryos' named entity 'titrations' named entity 'clones' named entity 'viruses' named entity 'virus' named entity 'microscope' named entity 'titer' named entity 'coronaviruses' named entity 'gelatin sponge' named entity 'fresh cultures' named entity 'saline' named entity 'virus' named entity 'viruses' named entity 'dye' named entity 'MRC' named entity 'Clonal' named entity 'incubator' named entity 'chicken' named entity 'virus' named entity 'inoculation' named entity 'virus' named entity 'virus' named entity 'infection' named entity 'eye examination' named entity 'virus' named entity 'HL1' named entity 'CO2' named entity 'Lungs' named entity 'virus' named entity 'virus' named entity 'virus' named entity 'influenza' named entity 'HL1' named entity 'infection' named entity 'morphology'

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