About: Preparative purification of glycyrrhizin extracted from the root of liquorice using high-speed counter-current chromatography

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About: Preparative purification of glycyrrhizin extracted from the root of liquorice using high-speed counter-current chromatography Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Preparative purification of glycyrrhizin extracted from the root of liquorice using high-speed counter-current chromatography
Creator	Chen, Feng Jiang, Yue Lu, Hai-Tao
Source	Elsevier; Medline; PMC
abstract	Abstract Glycyrrhizin is one of the main bioactive components in liquorice (Glycyrrhiza uralensis Fisch) which has recently been found to be highly active in inhibiting replication of the severe acute respiratory syndrome (SARS)-associated virus. The separation and purification of glycyrrhizin from a methanol–water (70:30 (v/v)) extract of liquorice roots was achieved using high-speed counter-current chromatography. The separation was performed at a preparative scale in a one-step separation with a two-phase solvent system composed of ethyl acetate–methanol–water (5:2:5 (v/v)). The lower phase was used as the mobile phase in the head-to-tail elution mode. The present method yielded 42.2mg glycyrrhizin at 96.8% purity from 130mg of the crude exact with 95.2% recovery as determined by HPLC analysis.
has issue date	2004-04-09(xsd:dateTime)
bibo:doi	10.1016/j.chroma.2004.01.033
bibo:pmid	15072305
has license	els-covid
sha1sum (hex)	6a4018b430b1cf33e7fdb8abecedbf8a4e74925b
schema:url	https://doi.org/10.1016/j.chroma.2004.01.033
resource representing a document's title	Preparative purification of glycyrrhizin extracted from the root of liquorice using high-speed counter-current chromatography
has PubMed Central identifier	PMC7125852
has PubMed identifier	15072305
schema:publication	Journal of Chromatography A
resource representing a document's body	covid:6a4018b430b1cf33e7fdb8abecedbf8a4e74925b#body_text
is schema:about of	named entity 'purification' named entity 'root' named entity 'chromatography' named entity 'HEAD' named entity 'ASSOCIATED VIRUS' named entity 'WATER' named entity 'CURRENT' named entity 'ACTIVE' named entity 'METHANOL' named entity 'SPEED' named entity 'EXTRACTED' named entity 'GLYCYRRHIZIN' named entity 'EXTRACT' named entity '130' named entity 'LIQUORICE' named entity 'CHROMATOGRAPHY' named entity 'LOWER' named entity 'BIOACTIVE COMPONENTS' named entity 'ETHYL ACETATE' named entity 'INHIBITING' named entity 'SCALE' named entity 'FISCH' named entity 'SYSTEM' named entity 'ELUTION' named entity 'STEP' named entity 'METHOD' named entity 'COUNTER' named entity 'USED' named entity 'MOBILE PHASE' named entity 'PURIFICATION' named entity 'ROOT' named entity 'CURRENT' named entity 'MODE' named entity 'SPEED' named entity 'SOLVENT' named entity 'LIQUORICE' named entity 'HIGH' named entity 'COUNTER' named entity 'CHROMATOGRAPHY' named entity 'HIGH' named entity 'PHASE' named entity 'PURIFICATION' named entity 'GLYCYRRHIZIN' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'USING' named entity 'RECOVERY' named entity 'ONE OF' named entity 'PRESENT' named entity 'MAIN' named entity 'DETERMINED BY' named entity 'ANALYSIS' named entity 'ROOTS' named entity 'USING' named entity 'TAIL' named entity 'REPLICATION' named entity 'HIGHLY' named entity 'FOUND' named entity 'EXACT' named entity 'RECENTLY' named entity 'HPLC' named entity 'PURITY' named entity 'PERFORMED' named entity 'COMPOSED OF' named entity '3A5' named entity 'SEPARATION' named entity 'inhibiting' named entity 'counter-current' named entity 'glycyrrhizin' named entity 'mobile phase' named entity 'mobile phase' named entity 'bioactive' named entity '95.2%' named entity 'severe acute respiratory syndrome' named entity 'chromatography' named entity 'glycyrrhizin' named entity 'solvent' named entity 'ethyl acetate' named entity 'n-butanol' named entity 'methanol'

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