About: Macrophage-Mediated Optic Neuritis Induced by Retrograde Axonal Transport of Spike Gene Recombinant Mouse Hepatitis Virus

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About: Macrophage-Mediated Optic Neuritis Induced by Retrograde Axonal Transport of Spike Gene Recombinant Mouse Hepatitis Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Macrophage-Mediated Optic Neuritis Induced by Retrograde Axonal Transport of Spike Gene Recombinant Mouse Hepatitis Virus
Creator	Das Sarma, Jayasri Biswas, Kaushiki Chatterjee, Dhriti Dutt, Mahasweta Goyal, Ashish Nassrallah, Mayssa Khan, Reas Shindler, Kenneth
Source	PMC
abstract	Following intracranial inoculation, neurovirulent mouse hepatitis virus (MHV) strains induce acute inflammation, demyelination and axonal loss in the CNS. Prior studies using recombinant MHV strains that differ only in the spike gene, which encodes a glycoprotein involved in virus-host cell attachment, demonstrated that spike mediates anterograde axonal transport of virus to the spinal cord. A demyelinating MHV strain induces optic neuritis, but whether this is due to retrograde axonal transport of viral particles to the retina, or if it is due to traumatic disruption of retinal ganglion cell axons during intracranial inoculation is not known. Using recombinant isogenic MHV strains, we examined the ability of recombinant MHV to induce optic neuritis by retrograde spread from the brain through the optic nerve into the eye following intracranial inoculation. Recombinant demyelinating MHV induced macrophage infiltration of optic nerves, demyelination and axonal loss whereas optic neuritis and axonal injury were minimal in mice infected with the non-demyelinating MHV strain that differs in the spike gene. Thus, optic neuritis was dependent on a spike glycoprotein-mediated mechanism of viral antigen transport along retinal ganglion cell axons. These data indicate that MHV spreads by retrograde axonal transport to the eye and that targeting spike protein interactions with axonal transport machinery is a potential therapeutic strategy for CNS viral infections and associated diseases.
has issue date	2011-06-01(xsd:dateTime)
bibo:doi	10.1097/nen.0b013e31821da499
bibo:pmid	21572336
has license	bronze-oa
sha1sum (hex)	6a39a657c4fddc7bfb9943d9df7e7c994ada4c88
schema:url	https://doi.org/10.1097/nen.0b013e31821da499
resource representing a document's title	Macrophage-Mediated Optic Neuritis Induced by Retrograde Axonal Transport of Spike Gene Recombinant Mouse Hepatitis Virus
has PubMed Central identifier	PMC3110774
has PubMed identifier	21572336
schema:publication	Journal of Neuropathology & Experimental Neurology
resource representing a document's body	covid:6a39a657c4fddc7bfb9943d9df7e7c994ada4c88#body_text
is schema:about of	named entity 'optic nerves' named entity 'data' named entity 'central nervous system' named entity 'interactions' named entity 'central nervous system' named entity 'mediates' named entity 'machinery' named entity 'particles' named entity 'eye' named entity 'axonal transport' named entity 'MHV' named entity 'axonal transport' named entity 'Recombinant' named entity 'Mouse' named entity 'spike' named entity 'diseases' named entity 'studies' named entity 'injury' named entity 'potential' named entity 'spike' named entity 'axonal transport' named entity 'involved' named entity 'Thus' named entity 'spike' named entity 'mechanism' named entity 'optic neuritis' named entity 'brain' named entity 'loss' named entity 'virus' named entity 'intracranial' named entity 'retinal ganglion cell' named entity 'cell attachment' named entity 'MHV' named entity 'inoculation' named entity 'optic nerve' named entity 'glycoprotein' named entity 'MHV' named entity 'recombinant' named entity 'optic nerves' named entity 'optic neuritis' named entity 'MHV' named entity 'retina' named entity 'axonal injury' named entity 'Macrophage' named entity 'Mouse Hepatitis Virus' named entity 'demyelination' named entity 'microglia' named entity 'inflammation' named entity 'mice' named entity 'mice' named entity 'biotin' named entity 'spinal cord' named entity 'optic nerve' named entity 'optic nerves' named entity 'MHV' named entity 'optic nerves' named entity 'retina' named entity 'spinal cord' named entity 'mouse hepatitis virus' named entity 'axons' named entity 'MHV' named entity 'molecular mechanisms' named entity 'meningitis' named entity 'recombinant' named entity 'spike protein' named entity 'inoculation' named entity 'cell fusion' named entity 'mice' named entity 'retina' named entity 'staining' named entity 'optic nerves' named entity 'optic neuritis' named entity 'mice' named entity 'mice'

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