About: Interferon alfacon 1 inhibits SARS-CoV infection In human bronchial epithelial Calu-3 cells

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About: Interferon alfacon 1 inhibits SARS-CoV infection In human bronchial epithelial Calu-3 cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Interferon alfacon 1 inhibits SARS-CoV infection In human bronchial epithelial Calu-3 cells
Creator	Kumaki, Yohichi Barnard, Dale Grant, Dixon Day, Craig Wandersee, Miles Blatt, Lawrence Madsen, Justin Schow, Bradley
Source	Elsevier; Medline; PMC
abstract	The primary targets for SARS-CoV infection are the epithelial cells in the respiratory and intestinal tract. The angiotensin-converting enzyme 2 (ACE-2) has been identified as a functional receptor for SARS-CoV. ACE-2 has been shown to be expressed at the apical domain of polarized Calu-3 cells. In this report, interferon alfacon 1 was examined for inhibitory activities against SARS-CoV on human lung carcinoma epithelial Calu-3 cell line and the other three African green monkey kidney epithelial cell lines. Interferon alfacon 1 demonstrated significant antiviral activity in neutral red uptake assay and virus yield reduction assay. The data might provide an important insight into the mechanism of pathogenesis of SARS-CoV allowing further development of antiviral therapies for treating SARS infections.
has issue date	2008-06-01(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2008.04.006
bibo:pmid	18406349
has license	bronze-oa
sha1sum (hex)	6a3962c1c62a360a3b8e7ae91ca96d515b83d566
schema:url	https://doi.org/10.1016/j.bbrc.2008.04.006
resource representing a document's title	Interferon alfacon 1 inhibits SARS-CoV infection In human bronchial epithelial Calu-3 cells
has PubMed Central identifier	PMC2441846
has PubMed identifier	18406349
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:6a3962c1c62a360a3b8e7ae91ca96d515b83d566#body_text
is schema:about of	named entity 'SARS-COV INFECTION' named entity 'respiratory' named entity 'infections' named entity 'pathogenesis' named entity 'ACE' named entity 'SARS-CoV' named entity 'SARS-CoV' named entity 'bronchial' named entity 'CALU-3' named entity 'PRIMARY' named entity 'INSIGHT' named entity 'ACE' named entity 'ASSAY' named entity 'SARS' named entity 'KIDNEY EPITHELIAL CELL' named entity 'ANGIOTENSIN-CONVERTING ENZYME 2' named entity 'LUNG CARCINOMA' named entity 'DOMAIN' named entity 'CELLS' named entity 'EXPRESSED' named entity 'INHIBITORY' named entity 'TREATING' named entity 'SARS-COV' named entity 'INFECTIONS' named entity 'TARGETS' named entity 'PROVIDE' named entity 'VIRUS' named entity 'DEVELOPMENT' named entity 'SARS-COV INFECTION' named entity 'AFRICAN GREEN MONKEY' named entity 'FUNCTIONAL' named entity 'APICAL' named entity 'THERAPIES' named entity 'RECEPTOR' named entity 'HUMAN LUNG' named entity 'SIGNIFICANT' named entity 'MECHANISM OF PATHOGENESIS' named entity 'EPITHELIAL' named entity 'CELL LINES' named entity 'ANTIVIRAL' named entity 'YIELD' named entity 'CALU-3 CELL' named entity 'CELLS' named entity 'HUMAN' named entity 'BRONCHIAL' named entity 'ACTIVITIES' named entity 'RESPIRATORY' named entity 'CALU-3' named entity 'ALLOWING' named entity 'EXAMINED FOR' named entity 'ANTIVIRAL ACTIVITY' named entity 'IDENTIFIED' named entity 'REPORT' named entity 'NEUTRAL RED UPTAKE ASSAY' named entity 'EPITHELIAL CELLS' named entity 'INTERFERON ' named entity 'INTESTINAL TRACT' named entity 'DATA' named entity 'REDUCTION' named entity 'INTERFERON ' named entity 'EPITHELIAL' named entity 'IMPORTANT' named entity 'CELL LINE' covid:arg/6a3962c1c62a360a3b8e7ae91ca96d515b83d566 named entity 'identified' named entity 'yield' named entity 'antiviral' named entity 'insight' named entity 'kidney' named entity 'mechanism' named entity 'development' named entity 'carcinoma' named entity 'virus' named entity 'apical'

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