About: Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety

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About: Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety
Creator	Balzarini, Jan Andrei, Graciela Snoeck, Robert Dra, Martin Kre Cmerová, Marcela Tomá S Tichý,
Source	Elsevier; Medline; PMC
abstract	Abstract Hexadecyloxypropyl esters of acyclic nucleoside phosphonates containing guanine (G) or hypoxanthine (Hx) and a (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] [(S)-HPMP] or 2-(2-phosphonoethoxy)ethyl (PEE) acyclic moiety have been prepared. The activity of the prodrugs was evaluated in vitro against different virus families. Whereas ester derivatives of PEEHx and (S)-HPMPHx were antivirally inactive, monoesters of PEEG, and mono- and diesters of (S)-HPMPG showed pronounced antiviral activity against vaccinia virus and/or herpesviruses. Monoesters of (S)-HPMPG emerged as the most potent and selective derivatives against these DNA viruses. None of the compounds were inhibitory against RNA viruses and retroviruses.
has issue date	2012-09-30(xsd:dateTime)
bibo:doi	10.1016/j.ejmech.2012.07.027
bibo:pmid	22858222
has license	els-covid
sha1sum (hex)	69e67469f4ce120d864971efb5e8b123905ec788
schema:url	https://doi.org/10.1016/j.ejmech.2012.07.027
resource representing a document's title	Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety
has PubMed Central identifier	PMC7115494
has PubMed identifier	22858222
schema:publication	European Journal of Medicinal Chemistry
resource representing a document's body	covid:69e67469f4ce120d864971efb5e8b123905ec788#body_text
is schema:about of	named entity 'Synthesis' named entity 'PRODRUGS' named entity 'ACYCLIC' named entity 'PEE' named entity 'EVALUATED' named entity 'THESE' named entity 'ACTIVITY' named entity 'DIFFERENT' named entity 'DNA VIRUSES' named entity 'ACYCLIC' named entity '28G' named entity 'HERPESVIRUSES' named entity 'RETROVIRUSES' named entity 'RNA VIRUSES' named entity '282' named entity 'ANTIVIRAL' named entity 'ANTIVIRAL ACTIVITY' named entity 'NUCLEOSIDE' named entity 'GUANINE' named entity 'ACTIVITIES' named entity '28S' named entity 'MOIETY' named entity 'PHOSPHONATES' named entity 'PREPARED' named entity 'MOIETY' named entity 'PRODRUGS' named entity 'NUCLEOSIDE' named entity 'HPMPG' named entity 'MONO' named entity 'INHIBITORY' named entity 'VIRUS' named entity 'FAMILIES' named entity 'ESTERS' named entity 'GUANINE' named entity 'INACTIVE' named entity 'HAVE' named entity 'DIESTERS' named entity 'PHOSPHONATES' named entity 'SELECTIVE' named entity 'HYDROXY' named entity 'IN VITRO' named entity 'CONTAINING' named entity 'ESTER' named entity 'SYNTHESIS' named entity 'HYPOXANTHINE' named entity 'CONTAINING' named entity 'HYPOXANTHINE' named entity '28S' named entity 'VACCINIA VIRUS' covid:arg/69e67469f4ce120d864971efb5e8b123905ec788 named entity 'guanine' named entity 'hypoxanthine' named entity 'virus' named entity 'The activity' named entity 'monoester' named entity 'prodrugs' named entity 'HSV' named entity 'phosphonate' named entity 'herpesviruses' named entity 'Acyclic' named entity 'HCl' named entity 'monoester' named entity 'MeOH' named entity 'cellular uptake' named entity 'DNA viruses' named entity 'nucleophilic' named entity 'HSV' named entity 'RNA viruses' named entity 'parainfluenza virus' named entity 'VZV' named entity 'DMF' named entity 'VZV' named entity 'Czech Republic' named entity 'HIV-1' named entity 'virus' named entity 'silica gel'

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