About: IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1(pdm09) Influenza

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1(pdm09) Influenza Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1(pdm09) Influenza
Creator	Ke, Changwen Li, Hui Lee, Nelson Cao, Bin Hu, Yunwen Lu, Hongzhou Horby, Peter Guan, Dawei Zhu, Zhaoqin Chan, Wai Kay, Paul Kwok, Kirsty Chan, Sheung Chi, Martin Ching, Ronald Ha, Claudia Hui, Cheong Hung, Tin-Nok Lin, Mulei Ma, Wan Shu, David Tam, Ting Wong, Rity Yung, Irene
Source	PMC
abstract	BACKGROUND. We examined associations between single-nucleotide polymorphisms (SNPs) of IFITM3, TLR3, and CD55 genes and influenza clinical outcomes in Chinese. METHODS. A multicenter study was conducted on 275 adult cases of avian (H7N9) and pandemic (H1N1(pdm09)) influenza. Host DNA was extracted from diagnostic respiratory samples; IFITM3 rs12252, TLR3 rs5743313, CD55 rs2564978, and TLR4 rs4986790/4986791 were targeted for genotyping (Sanger sequencing). The primary outcome analyzed was death. RESULTS. IFITM3 and TLR3 SNPs were in Hardy–Weinberg equilibrium; their allele frequencies (IFITM3/C-allele 0.56, TLR3/C-allele 0.88) were comparable to 1000 Genomes Han Chinese data. We found over-representation of homozygous IFITM3 CC (54.5% vs 33.2%; P = .02) and TLR3 CC (93.3% vs 76.9%; P = .04) genotypes among fatal cases. Recessive genetic models showed their significant independent associations with higher death risks (adjusted hazard ratio [aHR] 2.78, 95% confidence interval [CI] 1.29–6.02, and aHR 4.85, 95% CI 1.11−21.06, respectively). Cumulative effects were found (aHR 3.53, 95% CI 1.64−7.59 per risk genotype; aHR 9.99, 95% CI 1.27−78.59 with both). Results were consistent for each influenza subtype and other severity indicators. The CD55 TT genotype was linked to severity. TLR4 was nonpolymorphic. CONCLUSIONS. Host genetic factors may influence clinical outcomes of avian and pandemic influenza infections. Such findings have important implications on disease burden and patient care in at-risk populations.
has issue date	2017-07-01(xsd:dateTime)
bibo:doi	10.1093/infdis/jix235
bibo:pmid	28510725
has license	no-cc
sha1sum (hex)	69d39558af827978877ab3fe33ee0630a75ac0fe
schema:url	https://doi.org/10.1093/infdis/jix235
resource representing a document's title	IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1(pdm09) Influenza
has PubMed Central identifier	PMC7107409
has PubMed identifier	28510725
schema:publication	J Infect Dis
resource representing a document's body	covid:69d39558af827978877ab3fe33ee0630a75ac0fe#body_text
is schema:about of	named entity 'TLR3' named entity 'Genetic' named entity 'CHINESE' named entity 'OUTCOMES' named entity 'INFLUENZA' named entity 'GENES' named entity 'EXAMINED' named entity 'SEVERE' named entity 'PATIENTS' named entity 'TLR3' named entity 'GENETIC' named entity 'IFITM3' named entity 'IFITM3' named entity 'RISKS' named entity 'CD55 GENE' named entity 'CUMULATIVE' named entity 'INFLUENZA' named entity 'CHINESE' named entity 'ASSOCIATIONS' named entity 'CD55' named entity 'SINGLE-NUCLEOTIDE POLYMORPHISMS' named entity 'TLR3' named entity 'CLINICAL OUTCOMES' named entity 'H7N9' named entity 'SNPS' covid:arg/69d39558af827978877ab3fe33ee0630a75ac0fe named entity 'IFITM3' named entity 'TLR3' named entity 'influenza' named entity 'Guangdong' named entity 'general population' named entity 'peripheral blood mononuclear cell' named entity 'empirical distribution' named entity 'genetic risks' named entity '95% CI' named entity 'hazard ratio' named entity 'initial infection' named entity 'Cox regression' named entity 'regression analyses' named entity 'genotype' named entity 'H1N1' named entity 'confounders' named entity 'Chicago' named entity 'SNP' named entity 'H1N1' named entity 'public health' named entity 'influenza' named entity 'significant difference' named entity 'alleles' named entity 'recessive' named entity 'allele' named entity 'genotype' named entity 'complement activation' named entity 'ribonucleic acid' named entity 'sample size' named entity 'PCR amplification' named entity 'oxygen therapy' named entity 'IFITM3'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software