About: Ultrastructural Characterization of SARS Coronavirus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Ultrastructural Characterization of SARS Coronavirus
Creator	Tatti, Kathleen Rollin, Pierre Zaki, Sherif Goldsmith, Cynthia Ksiazek, Thomas Bankamp, Bettina Bellini, William Comer, James Lee, William Rota, Paul
Source	Medline; PMC
abstract	Severe acute respiratory syndrome (SARS) was first described during a 2002–2003 global outbreak of severe pneumonia associated with human deaths and person-to-person disease transmission. The etiologic agent was initially identified as a coronavirus by thin-section electron microscopic examination of a virus isolate. Virions were spherical, 78 nm in mean diameter, and composed of a helical nucleocapsid within an envelope with surface projections. Herein, we show that infection with the SARS-associated coronavirus resulted in distinct ultrastructural features: double-membrane vesicles, nucleocapsid inclusions, and large granular areas of cytoplasm. These three structures and the coronavirus particles were shown to be positive for viral proteins and RNA by using ultrastructural immunogold and in situ hybridization assays. In addition, ultrastructural examination of a bronchiolar lavage specimen from a SARS patient showed numerous coronavirus-infected cells with features similar to those in infected culture cells. Electron microscopic studies were critical in identifying the etiologic agent of the SARS outbreak and in guiding subsequent laboratory and epidemiologic investigations.
has issue date	2004-02-01(xsd:dateTime)
bibo:doi	10.3201/eid1002.030913
bibo:pmid	15030705
has license	no-cc
sha1sum (hex)	69ad5dfa7eb8ada52f203b2130a89ecf2ec5c6fa
schema:url	https://doi.org/10.3201/eid1002.030913
resource representing a document's title	Ultrastructural Characterization of SARS Coronavirus
has PubMed Central identifier	PMC3322934
has PubMed identifier	15030705
schema:publication	Emerg Infect Dis
resource representing a document's body	covid:69ad5dfa7eb8ada52f203b2130a89ecf2ec5c6fa#body_text
is schema:about of	named entity 'situ' named entity 'ultrastructural' named entity 'inclusions' named entity 'virus' named entity 'Electron microscopic' named entity 'critical' named entity 'infection' named entity 'ultrastructural' named entity 'cells' named entity 'GUIDING' named entity 'STRUCTURES' named entity 'ADDITION' named entity 'CULTURE' named entity 'FEATURES' named entity 'SARS' named entity 'SARS-ASSOCIATED CORONAVIRUS' named entity 'PATIENT' named entity 'PROJECTIONS' named entity 'GRANULAR' named entity 'USING' named entity 'VIRAL PROTEINS' named entity 'LAVAGE' named entity 'POSITIVE FOR' named entity 'MEAN DIAMETER' named entity 'INVESTIGATIONS' named entity 'ENVELOPE' named entity 'NUCLEOCAPSID' named entity 'ASSOCIATED WITH' named entity 'IMMUNOGOLD' named entity 'THESE' named entity 'INCLUSIONS' named entity 'DISEASE TRANSMISSION' named entity 'CHARACTERIZATION' named entity 'ETIOLOGIC AGENT' named entity 'IN SITU HYBRIDIZATION' named entity 'EXAMINATION' named entity 'LABORATORY' named entity 'INITIALLY' named entity 'MEMBRANE' named entity 'OUTBREAK' named entity 'SUBSEQUENT' named entity 'VESICLES' named entity 'GLOBAL' named entity 'HELICAL' named entity 'EPIDEMIOLOGIC' named entity 'PERSON' named entity 'CELLS' named entity 'PARTICLES' named entity 'ISOLATE' named entity 'SECTION' named entity 'CRITICAL' named entity 'SPECIMEN' named entity 'DEATHS' named entity 'DISTINCT' named entity 'CYTOPLASM' named entity 'LARGE' named entity 'STUDIES' named entity 'INFECTED' named entity 'SPHERICAL' named entity 'IDENTIFYING' named entity 'CORONAVIRUS' named entity 'MICROSCOPIC' named entity 'INFECTION' named entity 'DOUBLE' named entity 'ELECTRON' named entity 'SEVERE PNEUMONIA' named entity 'RNA' named entity 'COMPOSED OF' named entity 'MICROSCOPIC EXAMINATION' named entity 'VIRIONS' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'SIMILAR'

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