About: Detection of multiple respiratory pathogens during primary respiratory infection: nasal swab versus nasopharyngeal aspirate using real-time polymerase chain reaction

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About: Detection of multiple respiratory pathogens during primary respiratory infection: nasal swab versus nasopharyngeal aspirate using real-time polymerase chain reaction Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Detection of multiple respiratory pathogens during primary respiratory infection: nasal swab versus nasopharyngeal aspirate using real-time polymerase chain reaction
Creator	Bont, L Meerhoff, T Coenjaerts, F Houben, M Hofland, R Kimpen, J Schellevis, F
Source	Medline; PMC
abstract	In this study, we present the multiple detection of respiratory viruses in infants during primary respiratory illness, investigate the sensitivity of nasal swabs and nasopharyngeal aspirates, and assess whether patient characteristics and viral load played a role in the sensitivity. Healthy infants were included at signs of first respiratory tract infection. Paired nasopharyngeal aspirates and nasal swabs were collected. Real-time polymerase chain reaction (PCR) was carried out for 11 respiratory pathogens. Paired nasopharyngeal aspirates and nasal swabs were collected in 98 infants. Rhinovirus (n = 67) and respiratory syncytial virus (n = 39) were the most frequently detected. Co-infection occurred in 48% (n = 45) of the infants. The sensitivity of the nasal swab was lower than the nasopharyngeal aspirate, in particular, for respiratory syncytial virus (51% vs. 100%) and rhinovirus (75% vs. 97%). The sensitivity of the nasal swab was strongly determined by the cycle threshold (CT) value (p < 0.001). The sensitivity of the swab for respiratory syncytial virus, but not rhinovirus, was 100% in children with severe symptoms (score ≥11). It is concluded that, for community-based studies and surveillance purposes, the nasal swab can be used, though the sensitivity is lower than the aspirate, in particular, for the detection of mild cases of respiratory syncytial virus (RSV) infection.
has issue date	2010-01-29(xsd:dateTime)
bibo:doi	10.1007/s10096-009-0865-7
bibo:pmid	20111881
has license	cc-by-nc
sha1sum (hex)	6993451f527d3f206e315e404687a38c97a495ff
schema:url	https://doi.org/10.1007/s10096-009-0865-7
resource representing a document's title	Detection of multiple respiratory pathogens during primary respiratory infection: nasal swab versus nasopharyngeal aspirate using real-time polymerase chain reaction
has PubMed Central identifier	PMC2840676
has PubMed identifier	20111881
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:6993451f527d3f206e315e404687a38c97a495ff#body_text
is schema:about of	named entity 'INCLUDED' named entity 'CYCLE THRESHOLD' named entity 'DETERMINED BY' named entity 'NASOPHARYNGEAL ASPIRATE' named entity '2851' named entity 'PARTICULAR' named entity 'INVESTIGATE' named entity 'COLLECTED' named entity 'HEALTHY' named entity 'INFANTS' named entity 'VIRAL LOAD' named entity 'CARRIED' named entity 'nasal' named entity 'sensitivity' named entity 'primary' named entity 'respiratory' named entity 'DETECTION' named entity 'LOWER' named entity 'REAL-TIME POLYMERASE CHAIN REACTION' named entity 'NASOPHARYNGEAL' named entity 'DETECTED' named entity 'STUDY' named entity 'RESPIRATORY PATHOGENS' named entity 'RESPIRATORY INFECTION' named entity 'USING' named entity 'NASAL SWAB' named entity 'MULTIPLE' named entity 'PRIMARY' named entity 'REAL-TIME POLYMERASE CHAIN REACTION' named entity 'RESPIRATORY PATHOGENS' named entity 'SENSITIVITY' named entity 'FREQUENTLY' named entity '100%' named entity 'PATIENT CHARACTERISTICS' named entity 'RHINOVIRUS' named entity 'PRESENT' named entity 'ASSESS' named entity 'NASAL SWABS' named entity 'PLAYED' named entity 'RESPIRATORY ILLNESS' named entity 'ASPIRATES' named entity 'NASAL SWAB' named entity 'NASOPHARYNGEAL ASPIRATE' named entity 'PRIMARY' named entity 'PAIRED' named entity 'RESPIRATORY TRACT INFECTION' named entity 'DETECTION' named entity 'OCCURRED' named entity 'RESPIRATORY VIRUSES' named entity 'ROLE' named entity 'SIGNS' named entity 'CO-INFECTION' named entity 'MULTIPLE' named entity 'RESPIRATORY SYNCYTIAL VIRUS' covid:arg/6993451f527d3f206e315e404687a38c97a495ff named entity 'sensitivity' named entity 'sensitivity' named entity 'patient' named entity 'aspirates' named entity 'respiratory' named entity 'infants' named entity 'nasal swab' named entity 'nasopharyngeal' named entity 'nasopharyngeal' named entity 'respiratory syncytial virus' named entity 'aspirates' named entity 'viral load' named entity 'Rhinovirus' named entity 'pathogens' named entity 'real-time PCR' named entity 'type 1' named entity 'respiratory syncytial virus' named entity 'encephalomyocarditis virus' named entity 'pathogens' named entity 'Valencia, CA'

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