About: Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides
Creator	Schinazi, Raymond Chu, Chung Rao, Jagadeeshwar
Source	Elsevier; Medline; PMC
abstract	Abstract The enantiomerically pure carbocyclic purine and pyrimidine C-nucleosides 1–4 were synthesized via the key intermediate, 2,3-(isopropylidenedioxy)-4-(trityloxymethyl)-4-cyclopenten-1-ol (5), which was prepared from d-ribose in eight steps. Synthesized compounds were evaluated as potential antiviral agents against HIV, SARSCoV, Punta Toro, West Nile, and Cowpox viruses. However, only 9-deazaneplanocin A (1) exhibited moderate anti-HIV activity.
has issue date	2007-01-15(xsd:dateTime)
bibo:doi	10.1016/j.bmc.2006.10.043
bibo:pmid	17085053
has license	els-covid
sha1sum (hex)	698438de46236ed7f9df010ebb8558d27c8d0c55
schema:url	https://doi.org/10.1016/j.bmc.2006.10.043
resource representing a document's title	Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides
has PubMed Central identifier	PMC7127144
has PubMed identifier	17085053
schema:publication	Bioorganic & Medicinal Chemistry
resource representing a document's body	covid:698438de46236ed7f9df010ebb8558d27c8d0c55#body_text
is schema:about of	named entity 'ANTIVIRAL ACTIVITY' covid:arg/698438de46236ed7f9df010ebb8558d27c8d0c55 named entity 'PYRIMIDINE' named entity 'KEY' named entity 'WEST' named entity 'ANTI-HIV ACTIVITY' named entity 'PURE' named entity 'PURINE' named entity 'EVALUATED' named entity 'HIV' named entity 'D D' named entity 'NUCLEOSIDES' named entity 'PURINE' named entity 'ENANTIOSELECTIVE SYNTHESIS' named entity 'VIRUSES' named entity 'PREPARED' named entity 'POTENTIAL' named entity 'SYNTHESIZED' named entity 'INTERMEDIATE' named entity 'COWPOX' named entity 'MODERATE' named entity 'D-RIBOSE' named entity 'NUCLEOSIDES' named entity 'TORO' named entity 'PYRIMIDINE' named entity 'STEPS' named entity 'ANTIVIRAL AGENTS' named entity 'nucleosides' named entity 'antiviral activity' named entity 'amine' named entity 'solvent' named entity 'biologically active' named entity '5.5' named entity 'carbocyclic nucleoside' named entity 'm/z' named entity 'Chemistry' named entity 'filtration' named entity 'MeOH' named entity 'N 2' named entity 'Chemical shifts' named entity 'mmol' named entity 'ethyl acetate' named entity 'hepatitis B virus' named entity 'mmol' named entity 'carbocyclic' named entity 'New York' named entity 'pyrrolo' named entity 'solvent' named entity 'hydrogen chloride' named entity 'reaction mixture' named entity 'abacavir' named entity 'DMF' named entity 'hexane' named entity 'THF' named entity 'ether' named entity 'EtOAc' named entity 'silica gel' named entity 'malonate' named entity 'starting material' named entity 'guanidine' named entity 'mass spectrometer' named entity 'mmol' named entity 'chiral' named entity 'silica gel' named entity 'MeOH' named entity 'nitrogen' named entity 'column chromatography' named entity 'yellow fever' named entity 'urea' named entity 'cyclization' named entity 'hydrolytic cleavage' named entity 'carbocyclic' named entity 'MeOH' named entity 'nucleosides' named entity 'entecavir' named entity 'nucleosides' named entity 'mmol' named entity 'MeOH' named entity 'Nucleosides'

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