About: Use of Simple Laboratory Features to Distinguish the Early Stage of Severe Acute Respiratory Syndrome from Dengue Fever

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Use of Simple Laboratory Features to Distinguish the Early Stage of Severe Acute Respiratory Syndrome from Dengue Fever
Creator	Earnest, Arul Wilder-Smith, Annelies Paton, Nicholas
Source	Medline; PMC
abstract	Background. The diagnosis of severe acute respiratory syndrome (SARS) is difficult early in the illness, because its presentation resembles that of other nonspecific viral fevers, such as dengue. Dengue fever is endemic in many of the countries in which the large SARS outbreaks occurred in early 2003. Misdiagnosis may have serious public health consequences. We aimed to determine simple laboratory features to differentiate SARS from dengue. Methods. We compared the laboratory features of 55 adult patients with SARS at presentation (who were all admitted before radiological changes had occurred) and 147 patients with dengue. Features independently predictive of dengue were modeled by multivariate logistic regression to create a diagnostic tool with 100% specificity for dengue. Results. Multivariate analysis identified 3 laboratory features that together are highly predictive of a diagnosis of dengue and able to rule out the possibility of SARS: platelet count of <140 × 10(9) platelets/L, white blood cell count of <5 × 10(9)cells/L, and aspartate aminotransferase level of >34 IU/L. A combination of these parameters has a sensitivity of 75% and a specificity of 100%. Conclusions. Simple laboratory data may be helpful for the diagnosis of disease in adults admitted because of fever in areas in which dengue is endemic when the diagnosis of SARS needs to be excluded. Application of this information may help to optimize the use of isolation rooms for patients presenting with nonspecific fever.
has issue date	2004-12-15(xsd:dateTime)
bibo:doi	10.1086/426029
bibo:pmid	15578405
has license	no-cc
sha1sum (hex)	691a57b0df430602c13a0c40cdc2ca36b29a6798
schema:url	https://doi.org/10.1086/426029
resource representing a document's title	Use of Simple Laboratory Features to Distinguish the Early Stage of Severe Acute Respiratory Syndrome from Dengue Fever
has PubMed Central identifier	PMC7107824
has PubMed identifier	15578405
schema:publication	Clin Infect Dis
resource representing a document's body	covid:691a57b0df430602c13a0c40cdc2ca36b29a6798#body_text
is schema:about of	named entity '2003' named entity 'viral' named entity 'PUBLIC HEALTH' named entity 'DIFFERENTIATE' named entity 'ITS' named entity 'DETERMINE' named entity 'FEVERS' named entity 'EARLY STAGE' named entity 'DENGUE FEVER' named entity 'LABORATORY' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'MISDIAGNOSIS' named entity 'FEATURES' named entity 'USE OF' named entity 'CONSEQUENCES' named entity 'DENGUE FEVER' named entity 'DIFFICULT' named entity 'ENDEMIC' named entity 'DIAGNOSIS' named entity 'DENGUE' named entity 'EARLY' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'LABORATORY' named entity 'SIMPLE' named entity 'SIMPLE' named entity 'VIRAL' named entity 'SARS' named entity 'ILLNESS' named entity 'NONSPECIFIC' named entity 'OUTBREAKS' named entity 'LARGE' named entity 'PRESENTATION' named entity 'COUNTRIES' named entity 'BACKGROUND' named entity 'MAY HAVE' named entity 'FEATURES' named entity 'OCCURRED' named entity 'diagnosis' named entity 'public health' named entity 'dengue' named entity 'SARS' named entity 'endemic' named entity 'severe acute respiratory syndrome' named entity 'Dengue Fever' named entity 'SARS' named entity 'SARS' named entity 'SARS' named entity 'Asia' named entity 'biochemical' named entity 'SARS epidemic' named entity 'SARS' named entity 'platelet' named entity 'prognosis' named entity 'hematologic' named entity 'SARS' named entity 'neutrophil' named entity 'Asia' named entity 'dengue' named entity 'dengue fever' named entity 'area under the curve' named entity 'log-likelihood ratio test' named entity 'logistic regression' named entity 'SARS' named entity 'dengue' named entity 'low platelet count' named entity 'dengue' named entity 'constellation' named entity 'fever of unknown origin' named entity 'SARS' named entity 'dengue' named entity 'SARS' named entity 'dengue' named entity 'radiographic' named entity 'urea' named entity 'SARS' named entity 'fever' named entity 'serology' named entity 'AST' named entity 'leukocyte'

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