About: The CD8 T Cell Response to Respiratory Virus Infections

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The CD8 T Cell Response to Respiratory Virus Infections
Creator	Arens, Ramon Varga, Steven Schmidt, Megan Klonowski, Kim
topic	covid:68d01d19a8c579cd8c528e8e24cd0720216ba700#this
Source	Medline; PMC
abstract	Humans are highly susceptible to infection with respiratory viruses including respiratory syncytial virus (RSV), influenza virus, human metapneumovirus, rhinovirus, coronavirus, and parainfluenza virus. While some viruses simply cause symptoms of the common cold, many respiratory viruses induce severe bronchiolitis, pneumonia, and even death following infection. Despite the immense clinical burden, the majority of the most common pulmonary viruses lack long-lasting efficacious vaccines. Nearly all current vaccination strategies are designed to elicit broadly neutralizing antibodies, which prevent severe disease following a subsequent infection. However, the mucosal antibody response to many respiratory viruses is not long-lasting and declines with age. CD8 T cells are critical for mediating clearance following many acute viral infections in the lung. In addition, memory CD8 T cells are capable of providing protection against secondary infections. Therefore, the combined induction of virus-specific CD8 T cells and antibodies may provide optimal protective immunity. Herein, we review the current literature on CD8 T cell responses induced by respiratory virus infections. Additionally, we explore how this knowledge could be utilized in the development of future vaccines against respiratory viruses, with a special emphasis on RSV vaccination.
has issue date	2018-04-09(xsd:dateTime)
bibo:doi	10.3389/fimmu.2018.00678
bibo:pmid	29686673
has license	cc-by
sha1sum (hex)	68d01d19a8c579cd8c528e8e24cd0720216ba700
schema:url	https://doi.org/10.3389/fimmu.2018.00678
resource representing a document's title	The CD8 T Cell Response to Respiratory Virus Infections
has PubMed Central identifier	PMC5900024
has PubMed identifier	29686673
schema:publication	Front Immunol
resource representing a document's body	covid:68d01d19a8c579cd8c528e8e24cd0720216ba700#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/68d01d19a8c579cd8c528e8e24cd0720216ba700
is schema:about of	named entity 'CD8' named entity 'INFECTIONS' named entity 'RESPONSE TO' named entity 'RESPIRATORY VIRUS' named entity 'T CELL RESPONSE' named entity 'RSV infection' named entity 'viral shedding' named entity 'virus' named entity 'RSV' named entity 'HMPV' named entity 'CD8 T cell' named entity 'virus' named entity 'PD-1' named entity 'SARS' named entity 'current literature' named entity 'virus infection' named entity 'lumen' named entity 'phenotype' named entity 'CD8 T cells' named entity 'lower respiratory tract' named entity 'immunopathology' named entity 'CD8 T cell' named entity 'wild-type' named entity 'CD8 T cells' named entity 'neutralizing antibody' named entity 'cell lysis' named entity 'immunization' named entity 'CD8 T cell' named entity 'respiratory infections' named entity 'CD8 T cell' named entity 'glycoproteins' named entity 'immunopathology' named entity 'perforin' named entity 'RSV infection' named entity 'vaccine' named entity 'CD8 T cells' named entity 'peptide' named entity 'infection' named entity 'viral titers' named entity 'inflammation' named entity 'infection' named entity 'PD-1' named entity 'genetic reassortment' named entity 'virus' named entity 'TRAIL' named entity 'immunologically normal' named entity 'IL-10' named entity 'perforin' named entity 'ligands' named entity 'CD8 T cells' named entity 'immunopathology' named entity 'Virus' named entity 'TCM' named entity 'CD8 T cells' named entity 'granzyme' named entity 'immunopathology' named entity 'immunization' named entity 'IFN-γ' named entity 'immunopathology' named entity 'immunization' named entity 'CD8 T cells' named entity 'CD8 T cell' named entity 'symptom' named entity 'CD11a' named entity 'downregulate' named entity 'alveoli' named entity 'IAV' named entity 'SARS' named entity 'infection' named entity 'RSV' named entity 'CD8 T cell' named entity 'Tregs' named entity 'vasculature' named entity 'virus infection' named entity 'CD8 T cells' named entity 'CD8 T cell'

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