About: Dose–response time modelling for highly pathogenic avian influenza A (H5N1) virus infection

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About: Dose–response time modelling for highly pathogenic avian influenza A (H5N1) virus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dose–response time modelling for highly pathogenic avian influenza A (H5N1) virus infection
Creator	Huang, Y Haas, C Katayama, H Kitajima, M Watanabe, T
Source	Medline; PMC
abstract	Aims: To develop time‐dependent dose–response models for highly pathogenic avian influenza A (HPAI) of the H5N1 subtype virus. Methods and Results: A total of four candidate time‐dependent dose–response models were fitted to four survival data sets for animals (mice or ferrets) exposed to graded doses of HPAI H5N1 virus using the maximum‐likelihood estimation. A beta‐Poisson dose–response model with the N (50) parameter modified by an exponential‐inverse‐power time dependency or an exponential dose–response model with the k parameter modified by an exponential‐inverse time dependency provided a statistically adequate fit to the observed survival data. Conclusions: We have successfully developed the time‐dependent dose–response models to describe the mortality of animals exposed to an HPAI H5N1 virus. The developed model describes the mortality over time and represents observed experimental responses accurately. Significance and Impact of the Study: This is the first study describing time‐dependent dose–response models for HPAI H5N1 virus. The developed models will be a useful tool for estimating the mortality of HPAI H5N1 virus, which may depend on time postexposure, for the preparation of a future influenza pandemic caused by this lethal virus.
has issue date	2011-08-25(xsd:dateTime)
bibo:doi	10.1111/j.1472-765x.2011.03128.x
bibo:pmid	21790679
has license	no-cc
sha1sum (hex)	6844162f13a34ee4e6aaac53aa4e52c2ba49b35f
schema:url	https://doi.org/10.1111/j.1472-765x.2011.03128.x
resource representing a document's title	Dose–response time modelling for highly pathogenic avian influenza A (H5N1) virus infection
has PubMed Central identifier	PMC7197897
has PubMed identifier	21790679
schema:publication	Lett Appl Microbiol
resource representing a document's body	covid:6844162f13a34ee4e6aaac53aa4e52c2ba49b35f#body_text
is schema:about of	named entity 'study' named entity 'highly' named entity 'pathogenic' named entity 'virus' named entity 'time' named entity 'RESPONSE' named entity 'DOSE' named entity 'INVERSE' named entity 'MODELS' named entity 'Impact' named entity 'models' named entity 'mice' named entity 'dose-response' named entity 'describe' named entity 'virus' named entity 'exponential' named entity 'dose-response model' named entity 'candidate' named entity 'dependency' named entity 'tool' named entity 'experimental' named entity 'models' named entity 'Results' named entity 'describes' named entity 'data sets' named entity 'influenza pandemic' named entity 'HPAI H5N1' named entity 'H5N1' named entity 'virus' named entity 'highly pathogenic avian influenza' named entity 'virus' named entity 'dose-response' named entity 'virus' named entity 'dependency' named entity 'influenza pandemic' named entity 'virus infection' named entity 'avian influenza' named entity 'pathogen' named entity 'HPAI H5N1' named entity 'wild-type' named entity 'HPAI H5N1' named entity 'dose-response' named entity 'virus' named entity 'negative-sense RNA' named entity 'HPAI H5N1' named entity 'virus strain' named entity 'human infection' named entity 'virus' named entity 'virus infection' named entity 'mortality rate' named entity 'MLE' named entity 'neuraminidase' named entity 'mice' named entity 'virus' named entity 'best-fit' named entity 'Escherichia coli O157:H7' named entity 'dose-response' named entity 'influenza pandemic' named entity 'humans infected' named entity 'virus' named entity 'infection' named entity 'infectivity' named entity 'risk assessment' named entity 'pathogens' named entity 'inoculation' named entity 'eqn' named entity 'pathogenesis' named entity 'H1N2' named entity 'microbial' named entity 'inoculation' named entity 'risk assessment' named entity 'Orthomyxoviridae' named entity 'influenza virus' named entity 'HPAI H5N1' named entity 'infection' named entity 'viruses' named entity 'Kiso'

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