About: Surveillance Study of Influenza Occurrence and Immunity in a Wisconsin Cohort During the 2009 Pandemic

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Surveillance Study of Influenza Occurrence and Immunity in a Wisconsin Cohort During the 2009 Pandemic
Creator	Wang, Wei Viboud, Cecile Lo, Chia-Yun Gao, Jin Eichelberger, Maryna Epstein, Suzanne Misplon, Julia Stewart, Lucy Price, Graeme Bhattacharyya, Sanjib Dunham, Kimberly Garcia, Mayra Gorski, Jack Gradus, Steve Navidad, Jose Ozawa, Tatsuhiko Strobl, Susan Weiss, Carol
source	PMC
abstract	BACKGROUND. Antibody and T-cell immunity to conserved influenza virus antigens can protect animals against infection with diverse influenza strains. Although immunity against conserved antigens occurs in humans, whether such responses provide cross-protection in humans and could be harnessed as the basis for universal influenza vaccines is controversial. The 2009 pandemic provided an opportunity to investigate whether pre-existing cross-reactive immunity affected susceptibility to infection. METHODS. In 2009, we banked sera and peripheral blood mononuclear cells (PBMC) from blood donors, then monitored them for pandemic influenza infection (pH1N1) by polymerase chain reaction or seroconversion. Antibodies to hemagglutinin (HA), neuraminidase (NA), nucleoprotein (NP), matrix 2 (M2), and HA-pseudotypes were measured in sera. T-cell inteferon-γ enzyme-linked immunospot responses were measured in PBMC. RESULTS. There were 13 infections in 117 evaluable donors. Pre-existing T-cell reactivity to pH1N1 was substantial (of 153 donors tested, 146 had >100 spot-forming cells/10(6) cells). Antibodies reactive with pH1N1 were common: anti-NP (all donors) and anti-M2 (44% of donors). Pseudotype-neutralizing antibodies to H1 were detected, but not to highly conserved HA epitopes. Unexpectedly, donors with symptomatic pH1N1 infection had sharp rises in HA pseudotype-neutralizing antibodies, not only pH1N1 but also against multiple seasonal H1s. In addition, an exploratory study of a T-cell marker (response to NP(418-426)) identified probable infection missed by standard criteria. CONCLUSIONS. Although the number of infections was inadequate for conclusions about mechanisms of protection, this study documents the wide variety of pre-existing, cross-reactive, humoral and cellular immune responses to pandemic influenza virus antigens in humans. These responses can be compared with results of other studies and explored in universal influenza vaccine studies.
has issue date	2017-02-12(xsd:dateTime)
bibo:doi	10.1093/ofid/ofx023
bibo:pmid	28730155
has license	no-cc
sha1sum (hex)	68087817f91cea9c009a8d5e1ad9dd7af315ce83
schema:url	https://doi.org/10.1093/ofid/ofx023
resource representing a document's title	Surveillance Study of Influenza Occurrence and Immunity in a Wisconsin Cohort During the 2009 Pandemic
has PubMed Central identifier	PMC5510460
has PubMed identifier	28730155
schema:publication	Open Forum Infect Dis
resource representing a document's body	covid:68087817f91cea9c009a8d5e1ad9dd7af315ce83#body_text
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