About: Outbreak of Necrotizing Enterocolitis Caused by Norovirus in a Neonatal Intensive Care Unit

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Outbreak of Necrotizing Enterocolitis Caused by Norovirus in a Neonatal Intensive Care Unit
Creator	Bullitt, Esther Axelrod, Peter Donahue, Joan Robinson, Nancy Friss, Helena John, Keith Turcios-Ruiz, Reina
Source	Elsevier; Medline; PMC
abstract	Objectives To investigate an outbreak of necrotizing enterocolitis (NEC) in a neonatal intensive care unit (NICU) and to identify the etiology, describe illness risk factors, and develop control measures. Study design A retrospective case-control study was performed including newborns with NEC and newborns without NEC, examining demographic factors and exposures to medications, staff members, and procedures before illness. Stool samples from affected newborns were collected and tested for bacteria, parasites, and viruses. Results We confirmed a NEC outbreak in the NICU in January 1998 with 8 cases, including 2 deaths, clustered in time and space. Norovirus-like particles were identified in all available stools from cases; norovirus (NoV) was confirmed with reverse transcriptase polymerase chain reaction in 4 of 6 samples. NEC cases were younger, had lower Apgar scores, and received antibiotics longer than 25 control subjects. Three NICU health care personnel had more contact with cases than control subjects; 1 staff member recalled having gastroenteritis symptoms around the time of the outbreak. Conclusions This report associates NoV with NEC. NoV appeared to precipitate NEC in predisposed infants. Spatial clustering and epidemiologic links between cases and a health care worker with gastroenteritis suggests that NoV should be investigated among the etiologies of NEC outbreaks and that interventions targeted to interruption of NoV transmission should be considered.
has issue date	2008-09-30(xsd:dateTime)
bibo:doi	10.1016/j.jpeds.2008.04.015
bibo:pmid	18534621
has license	els-covid
sha1sum (hex)	677e721c74f2f5903acfc1373e01f889945e05ec
schema:url	https://doi.org/10.1016/j.jpeds.2008.04.015
resource representing a document's title	Outbreak of Necrotizing Enterocolitis Caused by Norovirus in a Neonatal Intensive Care Unit
has PubMed Central identifier	PMC7094480
has PubMed identifier	18534621
schema:publication	The Journal of Pediatrics
resource representing a document's body	covid:677e721c74f2f5903acfc1373e01f889945e05ec#body_text
is schema:about of	named entity 'necrotizing enterocolitis' named entity 'Necrotizing' named entity 'NEONATAL INTENSIVE CARE UNIT' named entity 'OUTBREAK' named entity 'NECROTIZING ENTEROCOLITIS' named entity 'NECROTIZING ENTEROCOLITIS' named entity 'CAUSED BY' named entity 'NEONATAL INTENSIVE CARE UNIT' named entity 'NOROVIRUS' named entity 'ETIOLOGY' named entity 'TO INVESTIGATE' named entity 'MEASURES' named entity 'TO IDENTIFY' named entity 'ILLNESS' named entity 'RISK FACTORS' named entity 'OUTBREAK' named entity 'DESCRIBE' named entity 'OBJECTIVES' named entity 'CONTROL' covid:arg/677e721c74f2f5903acfc1373e01f889945e05ec named entity 'risk factors' named entity 'investigate' named entity 'develop' named entity 'etiology' named entity 'Norovirus' named entity 'peritoneal fluid' named entity 'immunoassay' named entity 'NEC' named entity 'statistical test' named entity 'abdominal distention' named entity 'gestational age' named entity 'multiple birth' named entity 'disinfection' named entity 'surfactant' named entity 'diagnostic testing' named entity 'NEC' named entity 'intubation' named entity 'NICU' named entity 'NEC' named entity 'NEC' named entity 'NICU' named entity 'NEC' named entity 'NEC' named entity 'NEC' named entity 'Campylobacter' named entity 'caffeine' named entity 'NICU' named entity 'NEC' named entity 'antibiotics' named entity 'antibiotic' named entity 'hand washing' named entity 'NICU' named entity 'exchange transfusion' named entity 'histamine' named entity 'risk factors' named entity 'Southern hybridization' named entity '95% CI' named entity 'NICU' named entity 'indomethacin' named entity 'Hand washing' named entity 'microscopic examination' named entity 'lethargy' named entity 'platelet counts' named entity 'coxsackie B2' named entity 'EpiInfo' named entity 'Clostridium difficile' named entity 'vomiting' named entity 'neonatal' named entity 'endemic' named entity 'virus' named entity 'vomiting' named entity 'histamine' named entity 'NEC' named entity 'adenovirus' named entity 'reverse transcriptase polymerase chain reaction'

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