About: Multiple organ failure – the discrepancy between our scientific knowledge and understanding and the management of our patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Multiple organ failure – the discrepancy between our scientific knowledge and understanding and the management of our patients
Creator	Baue, Arthur
Source	PMC
abstract	The excitement of molecular biology and of genetic knowledge and their possibilities must be balanced against our limitations in using this information for the care of our patients. There is a great discrepancy between what we know and what we can do. There are many reasons for this. A major one is that science must simplify/reduce the variables in experimentation and then generalize in terms of a specific factor or effect, whereas patients are complex with variables that we do not yet understand completely. This powerful science is now teaching us about the genetic diversity in both susceptibility and outcome of disease, and the diversity in life experiences and antigen exposures. Clinicians have tried to lump together and treat in a similar way many diverse human diseases. This has not worked well. Pancreatitis and perforated diverticulitis both produce inflammation and sepsis, but they are different processes and may both lead to multiple organ failure. This lumping together has contributed to the failure of so-called magic bullets. There are new contributors to organ damage. Gender, lifestyle and prior disease differences also complicate the care of patients. Despite this, we are slowly and gradually improving the care of our surgical patients by careful pre-, intra- and postoperative support and better, simpler and safer operations.
has issue date	2000-10-19(xsd:dateTime)
bibo:doi	10.1007/s004230000162
bibo:pmid	11131246
has license	no-cc
sha1sum (hex)	6750d3e682b94b9c2eeda57c408245d1d680b0fb
schema:url	https://doi.org/10.1007/s004230000162
resource representing a document's title	Multiple organ failure – the discrepancy between our scientific knowledge and understanding and the management of our patients
has PubMed Central identifier	PMC7101854
has PubMed identifier	11131246
schema:publication	Langenbecks Arch Surg
resource representing a document's body	covid:6750d3e682b94b9c2eeda57c408245d1d680b0fb#body_text
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