About: Fundamentals of G-quadruplex biology

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fundamentals of G-quadruplex biology
Creator	Johnson, F
Source	Elsevier; Medline; PMC
abstract	Several decades elapsed between the first descriptions of G-quadruplex nucleic acid structures (G4s) assembled in vitro and the emergence of experimental findings indicating that such structures can form and function in living systems. A large body of evidence now supports roles for G4s in many aspects of nucleic acid biology, spanning processes from transcription and chromatin structure, mRNA processing, protein translation, DNA replication and genome stability, and telomere and mitochondrial function. Nonetheless, it must be acknowledged that some of this evidence is tentative, which is not surprising given the technical challenges associated with demonstrating G4s in biology. Here I provide an overview of evidence for G4 biology, focusing particularly on the many potential pitfalls that can be encountered in its investigation, and briefly discuss some of broader biological processes that may be impacted by G4s including cancer.
has issue date	2020-07-30(xsd:dateTime)
bibo:doi	10.1016/bs.armc.2020.06.004
bibo:pmid	32836507
has license	no-cc
sha1sum (hex)	66fb706a9334151cd3cab0175640911e345c69ad
schema:url	https://doi.org/10.1016/bs.armc.2020.06.004
resource representing a document's title	Fundamentals of G-quadruplex biology
has PubMed Central identifier	PMC7392596
has PubMed identifier	32836507
schema:publication	Annu Rep Med Chem
resource representing a document's body	covid:66fb706a9334151cd3cab0175640911e345c69ad#body_text
is schema:about of	named entity 'G-quadruplex' named entity 'ligand' named entity 'mitochondrial' named entity 'eQTLs' named entity 'antibody' named entity 'G4s' named entity 'base pair' named entity 'replication fork' named entity 'intramolecular' named entity 'AID' named entity 'C. elegans' named entity 'telomeres' named entity 'G4s' named entity 'replication fork' named entity 'gene' named entity 'Apobec' named entity 'oxidation' named entity 'S. cerevisiae' named entity 'yeast' named entity 'yeast' named entity 'cell biology' named entity 'heme' named entity 'PTM' named entity 'gene' named entity 'oxidation' named entity 'G4s' named entity 'amino acids' named entity 'staining' named entity 'G-quadruplexes' named entity 'telomeric' named entity 'mutation' named entity 'inhibit the growth' named entity 'telomeres' named entity 'DNA-PK' named entity 'genome' named entity 'gene' named entity 'FANCJ' named entity 'telomere' named entity 'post-translational modification' named entity 'POT1' named entity 'telomerase' named entity 'S-phase' named entity 'antibody' named entity 'telomerase' named entity 'chicken' named entity 'AID' named entity 'double strand breaks' named entity 'G4s' named entity 'G4s' named entity 'porphyrin' named entity 'G4s' named entity 'nucleosome' named entity 'telomere' named entity 'G4s' named entity 'telomere' named entity 'BLM' named entity 'CST' named entity 'G4s' named entity 'small molecule' named entity 'hemin' named entity 'guanines' named entity 'antibody' named entity 'eukaryotes' named entity 'guanines' named entity 'gene products' named entity 'G4s' named entity 'mRNAs' named entity 'nucleosome' named entity 'intramolecular' named entity 'antibody' named entity 'telomerase' named entity 'IgG' named entity 'replication fork' named entity 'staining' named entity 'nucleases' named entity 'G4s' named entity 'phenotype' named entity 'telomeres' named entity 'telomerase' named entity 'antigen' named entity 'template strand'

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