About: Viable circulating endothelial cells and their progenitors are increased in Covid-19 patients

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About: Viable circulating endothelial cells and their progenitors are increased in Covid-19 patients Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viable circulating endothelial cells and their progenitors are increased in Covid-19 patients
Creator	Cremonesi, Paola Bertolini, Francesco Caccia, Sonia Cogliati, Chiara Gidaro, Antonio Gregato, Giuliana Gusso, Luca Mancuso, Patrizia Quarna, Jessica Raveane, Alessandro
Source	MedRxiv
abstract	During the course of Covid-19, the disease caused by the new Coronavirus SARS-CoV-2, thrombotic phenomena and/or diffuse vascular damage are frequent, and viral elements have been observed within endothelial cells. Circulating endothelial cells (CECs) and their progenitors (CEPs) are increased in cardiovascular, thrombotic, infectious and cancer diseases. Using a validated flow cytometry procedure, we found that viable CEPs/mL were significantly increased in Covid-19 patients compared to healthy controls. This increase was observed in patients with mild symptoms and not further augmented in patients with severe symptoms. In patients who recovered, CEPs decreased, but were in a range still significantly higher than normal controls. Regarding mature CECs, in Covid-19 patients their absolute number was similar to those observed in healthy controls, but the viable/apoptotic CEC ratio was significantly different. Both mild and severe Covid-19 patients had significantly more viable CECs compared to healthy controls. Patients who recovered had significantly less CECs/mL when compared to controls as well as to mild and severe Covid-19 patients. A positive correlation was found between the copies of SARS-CoV-2 RNA in the cellular fraction and apoptotic CEPs/mL in severe Covid-19 patients. These findings suggest that CECs and CEPs might be investigated as candidate biomarkers of endothelial damage in Covid-19 patients.
has issue date	2020-05-05(xsd:dateTime)
bibo:doi	10.1101/2020.04.29.20085878
has license	medrxiv
sha1sum (hex)	66d0cbe845921d561f8443fab0daedfa565b878d
schema:url	https://doi.org/10.1101/2020.04.29.20085878
resource representing a document's title	Viable circulating endothelial cells and their progenitors are increased in Covid-19 patients
resource representing a document's body	covid:66d0cbe845921d561f8443fab0daedfa565b878d#body_text
is schema:about of	named entity 'patients' named entity 'patients' named entity 'copies' named entity 'biomarkers' named entity 'Covid-19' named entity 'endothelial cells' named entity 'ENDOTHELIAL CELLS' named entity 'CAUSED BY' named entity 'COVID-19' named entity 'VASCULAR' named entity 'INCREASE' named entity 'HAVE' covid:arg/66d0cbe845921d561f8443fab0daedfa565b878d named entity 'disease' named entity 'viral' named entity 'SARS-CoV-2' named entity 'severe' named entity 'endothelial cells' named entity 'Covid-19' named entity 'symptoms' named entity 'patients' named entity 'Student's t-test' named entity 'flow cytometry' named entity 'leukocyte count' named entity 'controls' named entity 'candidate' named entity 'mature' named entity 'viable' named entity 'patients' named entity 'SARS-CoV-2' named entity 'Covid' named entity 'Covid' named entity 'apoptotic' named entity 'positive correlation' named entity 'Coronavirus' named entity 'absolute number' named entity 'Covid-19' named entity 'Covid' named entity 'SARS-CoV-2' named entity 'endothelial cells' named entity 'patients' named entity 'medRxiv' named entity 'endothelial cells' named entity 'biomarkers' named entity 'RT-PCR' named entity 'RNA' named entity 'monoclonal antibodies' named entity 'preprint' named entity 'SARS-CoV-2' named entity 'preprint' named entity 'doi' named entity 'apoptotic' named entity 'eosinophils' named entity 'Covid-19' named entity 'apoptotic' named entity 'preprint' named entity 'normality test' named entity 'Covid' named entity 'medRxiv' named entity 'platelets' named entity 'preprint' named entity 'red blood cell' named entity 'medRxiv' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'preprint' named entity 'Beckman Coulter' named entity 'Covid' named entity 'Covid-19' named entity 'biomarkers' named entity 'peer review' named entity 'Coronavirus' named entity 'peer review' named entity 'vascular endothelium' named entity 'lymphocytes' named entity 'Apoptotic' named entity 'preprint'

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