About: Use of Leukoreduced Blood Does Not Reduce Infection, Organ Failure, or Mortality Following Trauma

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Use of Leukoreduced Blood Does Not Reduce Infection, Organ Failure, or Mortality Following Trauma
Creator	Englehart, Michael Gee, Arvin Luem, Nick Schreiber, Martin Underwood, Samantha Wiesberg, Tracy Gordon, A Ae, Cho Ae, Jerome Ae, Melanie Ae, Riha Boshkov, K David, Ae Lynn, A
Source	PMC
abstract	BACKGROUND: Leukoreduced (LR) blood has been demonstrated to reduce morbidity and mortality in high-risk surgical patients, but not in trauma patients. The objective of the present study was to determine the effect of LR blood on morbidity and mortality. We hypothesized that the use of LR blood does not improve outcome in trauma patients. METHODS: This study was a retrospective cohort analysis of trauma patients transfused at a level 1 Trauma Center from 2001 to 2004. Between 2002 and 2003, LR blood was transfused. Prior to that time and subsequent to it, non-leukoreduced (NLR) blood was transfused. This created two historical comparison groups. Data collected included patient demographics, units of blood transfused, intensive care unit (ICU) and hospital days, ventilator days, injury severity score (ISS), mortality, presence of acute respiratory distress syndrome (ARDS), and infectious complications. A multiple organ dysfunction syndrome (MODS) score was calculated. RESULTS: The distribution of patients was as follows: 284 patients received only NLR blood, 153 received only LR blood, and 58 received at least one unit of each. The mean ISS was similar (NLR: 26, LR: 24; P > 0.1). No differences were seen between groups in units transfused (6.2 vs. 5.5), number of ICU days (8.2 vs. 9.0), number of hospital days (16.9 vs. 18.6), number of ventilator days (6.1 vs. 5.7), incidence of ARDS (8.3% vs. 8.5%), MODS score (5.5 vs. 5.9), mortality rate (15.1% vs. 15.7%), or infection rate (36% vs. 30%) (P > 0.1). CONCLUSIONS: This study represents the largest series comparing trauma patients who received either LR or standard blood transfusions. The use of LR blood does not improve outcome in trauma patients.
has issue date	2009-05-19(xsd:dateTime)
bibo:doi	10.1007/s00268-009-0076-5
bibo:pmid	19452207
has license	no-cc
sha1sum (hex)	66a5a46b2fc86476cb747cac80fa222e5632cff1
schema:url	https://doi.org/10.1007/s00268-009-0076-5
resource representing a document's title	Use of Leukoreduced Blood Does Not Reduce Infection, Organ Failure, or Mortality Following Trauma
has PubMed Central identifier	PMC7101844
has PubMed identifier	19452207
schema:publication	World J Surg
resource representing a document's body	covid:66a5a46b2fc86476cb747cac80fa222e5632cff1#body_text
is schema:about of	named entity 'BLOOD' named entity 'MORBIDITY AND MORTALITY' named entity 'BACKGROUND' named entity 'morbidity' named entity 'patients' named entity 'trauma patients' named entity 'morbidity' named entity 'high-risk' named entity 'Organ Failure' named entity 'infection' named entity 'infection' named entity 'infection' named entity 'anergy' named entity 'retrospective cohort' named entity 'Fisher's exact test' named entity 'NLR' named entity 'rash' named entity 'Oregon Health & Science University' named entity 'type of blood' named entity 'hemolytic' named entity 'outcome measure' named entity '5.5' named entity 'bacteremia' named entity 'mixed group' named entity 'allogeneic' named entity 'blood transfusion' named entity 'ICU' named entity 'leukocytes' named entity 'morbidity' named entity 'blood transfusion' named entity 'data set' named entity 'trauma patients' named entity 'infection' named entity 'blood bank' named entity 'trauma patients' named entity 'American Red Cross' named entity 'leukoreduction' named entity 'mixed group' named entity 'infection' named entity 'SPSS' named entity 'HIV' named entity '13.0' named entity 'Chicago' named entity 'infection' named entity 'MODS' named entity 'ICU' named entity 'right-sided heart failure' named entity 'trauma patients' named entity 'Mann-Whitney' named entity 'hepatitis' named entity 'MODS' named entity 'NLR' named entity 'outcome measure' named entity 'mixed group' named entity 'Mixed group' named entity 'cryoprecipitate' named entity 'trauma patients' named entity 'PRBC' named entity 'MODS' named entity 'ANOVA' named entity 'transfusion reactions' named entity 'catheter' named entity 'transfusion reactions' named entity 'analysis of variance' named entity 'Febrile' named entity 'leukoreduction' named entity 'blood transfusion' named entity 'UTI'

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