About: Correlation between the presence of neutralizing antibodies against porcine circovirus 2 (PCV2) and protection against replication of the virus and development of PCV2-associated disease

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About: Correlation between the presence of neutralizing antibodies against porcine circovirus 2 (PCV2) and protection against replication of the virus and development of PCV2-associated disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Correlation between the presence of neutralizing antibodies against porcine circovirus 2 (PCV2) and protection against replication of the virus and development of PCV2-associated disease
Creator	Nauwynck, Hans Bøtner, Anette Nielsen, Jens Lefebvre, David Meerts, Peter Misinzo, Gerald Kristensen, Charlotte
Source	Medline; PMC
abstract	BACKGROUND: In a previous study, it was demonstrated that high replication of Porcine circovirus 2 (PCV2) in a gnotobiotic pig was correlated with the absence of PCV2-neutralizing antibodies. The aim of the present study was to investigate if this correlation could also be found in SPF pigs in which PMWS was experimentally reproduced and in naturally PMWS-affected pigs. RESULTS: When looking at the total anti-PCV2 antibody titres, PMWS-affected and healthy animals seroconverted at the same time point, and titres in PMWS-affected animals were only slightly lower compared to those in healthy animals. In healthy animals, the evolution of PCV2-neutralizing antibodies coincided with that of total antibodies. In PMWS-affected animals, neutralizing antibodies could either not be found (sera from field studies) or were detected in low titres between 7 and 14 DPI only (sera from experimentally inoculated SPF pigs). Differences were also found in the evolution of specific antibody isotypes titres against PCV2. In healthy pigs, IgM antibodies persisted until the end of the study, whereas in PMWS-affected pigs they quickly decreased or remained present at low titres. The mean titres of other antibody isotypes (IgG1, IgG2 and IgA), were slightly lower in PMWS-affected pigs compared to their healthy group mates at the end of each study. CONCLUSION: This study describes important differences in the development of the humoral immune response between pigs that get subclinically infected with PCV2 and pigs that experience a high level of PCV2-replication which in 3 of 4 experiments led to the development of PMWS. These observations may contribute to a better understanding of the pathogenesis of a PCV2-infection.
has issue date	2006-01-30(xsd:dateTime)
bibo:doi	10.1186/1746-6148-2-6
bibo:pmid	16445856
has license	cc-by
sha1sum (hex)	66a1d5898c1fb5c8e8554f92e446d262abb10fdb
schema:url	https://doi.org/10.1186/1746-6148-2-6
resource representing a document's title	Correlation between the presence of neutralizing antibodies against porcine circovirus 2 (PCV2) and protection against replication of the virus and development of PCV2-associated disease
has PubMed Central identifier	PMC1386657
has PubMed identifier	16445856
schema:publication	BMC Vet Res
resource representing a document's body	covid:66a1d5898c1fb5c8e8554f92e446d262abb10fdb#body_text
is schema:about of	named entity 'investigate' named entity 'neutralizing antibodies' named entity 'development' named entity 'RESEARCH' named entity 'TO INVESTIGATE' named entity 'PIG' named entity 'AIM' named entity 'CORRELATED' named entity 'PIGS' named entity 'PREVIOUS' named entity 'REPLICATION' named entity 'ABSENCE OF' named entity 'VIRUS' named entity 'VETERINARY' named entity 'DEVELOPMENT' named entity 'NEUTRALIZING ANTIBODIES' named entity 'PORCINE CIRCOVIRUS 2' named entity 'PRESENCE OF' named entity 'CORRELATION' named entity 'ASSOCIATED' named entity 'BMC' named entity 'REPLICATION' named entity 'AFFECTED' named entity 'PORCINE CIRCOVIRUS 2' named entity 'CORRELATION' named entity 'HIGH' named entity 'DEMONSTRATED' named entity 'PROTECTION' named entity 'DISEASE' named entity 'STUDY' named entity 'PMWS' named entity 'SPF' named entity 'PRESENT' named entity 'BACKGROUND' named entity 'NEUTRALIZING ANTIBODIES' covid:arg/66a1d5898c1fb5c8e8554f92e446d262abb10fdb named entity 'pigs' named entity 'study' named entity 'demonstrated' named entity 'reproduced' named entity 'experimentally' named entity 'neutralizing antibodies' named entity 'pig' named entity 'PMWS' named entity 'PCV2' named entity 'PCV2' named entity 'neutralizing antibodies' named entity 'virus' named entity 'PCV2' named entity 'PMWS' named entity 'PMWS' named entity 'antibody' named entity 'peroxidase' named entity 'goat' named entity 'inguinal lymph nodes' named entity 'SPF' named entity 'experimental studies' named entity 'PCV2' named entity 'mastitis' named entity 'IgM' named entity 'weaning' named entity 'viral infections' named entity 'cell cultures' named entity 'IgM' named entity 'gnotobiotic' named entity 'IgG2' named entity 'virus' named entity 'parallel evolution' named entity 'PCV2' named entity 'PCV2' named entity 'PMWS' named entity 'neutralizing antibody' named entity 'IgM' named entity 'Danish' named entity 'PMWS'

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