About: Autophagy Negatively Regulates Transmissible Gastroenteritis Virus Replication

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Autophagy Negatively Regulates Transmissible Gastroenteritis Virus Replication
Creator	Zhang, Jian Wang, Yue Feng, Li Gu, Weihong Guo, Longjun Li, Ren Luo, Xiaolei Yu, Haidong Shen, Nan Yang, Lijun Xu, Yunfei
Source	Medline; PMC
abstract	Autophagy is an evolutionarily ancient pathway that has been shown to be important in the innate immune defense against several viruses. However, little is known about the regulatory role of autophagy in transmissible gastroenteritis virus (TGEV) replication. In this study, we found that TGEV infection increased the number of autophagosome-like double- and single-membrane vesicles in the cytoplasm of host cells, a phenomenon that is known to be related to autophagy. In addition, virus replication was required for the increased amount of the autophagosome marker protein LC3-II. Autophagic flux occurred in TGEV-infected cells, suggesting that TGEV infection triggered a complete autophagic response. When autophagy was pharmacologically inhibited by wortmannin or LY294002, TGEV replication increased. The increase in virus yield via autophagy inhibition was further confirmed by the use of siRNA duplexes, through which three proteins required for autophagy were depleted. Furthermore, TGEV replication was inhibited when autophagy was activated by rapamycin. The antiviral response of autophagy was confirmed by using siRNA to reduce the expression of gene p300, which otherwise inhibits autophagy. Together, the results indicate that TGEV infection activates autophagy and that autophagy then inhibits further TGEV replication.
has issue date	2016-03-31(xsd:dateTime)
bibo:doi	10.1038/srep23864
bibo:pmid	27029407
has license	cc-by
sha1sum (hex)	668aeb98c355caf8edcbbcb808215f26e7c388ad
schema:url	https://doi.org/10.1038/srep23864
resource representing a document's title	Autophagy Negatively Regulates Transmissible Gastroenteritis Virus Replication
has PubMed Central identifier	PMC4814908
has PubMed identifier	27029407
schema:publication	Sci Rep
resource representing a document's body	covid:668aeb98c355caf8edcbbcb808215f26e7c388ad#body_text
is schema:about of	named entity 'LC3-II' named entity 'VIRUS' named entity 'NUMBER OF' named entity 'USE OF' named entity 'REQUIRED' named entity 'RELATED' named entity 'STUDY' named entity 'HOST CELLS' named entity 'CONFIRMED BY' named entity 'INFECTED' named entity 'EXPRESSION' named entity 'MARKER PROTEIN' named entity 'OCCURRED' named entity 'DEPLETED' named entity 'SINGLE' named entity 'TRIGGERED' named entity 'autophagy' named entity 'confirmed' named entity 'rapamycin' named entity 'cells' named entity 'host' named entity 'vesicles' named entity 'OPEN' named entity 'ANTIVIRAL RESPONSE' named entity 'YIELD' named entity 'DEFENSE' named entity 'PATHWAY' named entity 'ACTIVATES' named entity 'PROTEINS' named entity 'LIKE' named entity 'VESICLES' named entity 'PHENOMENON' named entity 'CELLS' named entity 'FLUX' named entity 'LITTLE' named entity 'AUTOPHAGY' named entity 'FOUND' named entity 'IMPORTANT' named entity 'KNOWN' named entity 'WORTMANNIN' named entity 'ANCIENT' covid:arg/668aeb98c355caf8edcbbcb808215f26e7c388ad named entity 'AUTOPHAGY' named entity 'VIRUS REPLICATION' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'RESULTS' named entity 'USING' named entity 'REPLICATION' named entity 'DOUBLE' named entity 'CYTOPLASM' named entity 'INFECTION' named entity 'OPEN' named entity 'TO REDUCE' named entity 'RESPONSE' named entity 'ADDITION' named entity 'IMMUNE' named entity 'INHIBITION' named entity 'VIRUSES' named entity 'TRANSMISSIBLE GASTROENTERITIS VIRUS' named entity 'VIRUS REPLICATION' named entity 'RAPAMYCIN' named entity 'MEMBRANE' named entity 'GENE' named entity 'ABOUT' named entity 'INCREASE' named entity 'INCREASED' named entity 'AUTOPHAGOSOME' named entity 'LY294002' named entity 'INCREASED AMOUNT' named entity 'P300' named entity 'ACTIVATED'

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