About: Reversible and cachexia‐associated feline skin fragility syndrome in three cats

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About: Reversible and cachexia‐associated feline skin fragility syndrome in three cats Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Reversible and cachexia‐associated feline skin fragility syndrome in three cats
Creator	Brachelente, Chiara Furiani, Nicla Porcellato, Ilaria
source	Medline; PMC
abstract	BACKGROUND: Feline skin fragility syndrome (FSFS) is an acquired disorder characterized by altered collagen production resulting in an extremely thin and fragile skin. FSFS is associated with diseases characterized by excessive steroidal hormones that can inhibit collagen synthesis. It is also described concomitantly with severe inflammatory, infectious or neoplastic conditions where the pathogenesis remains largely unknown. OBJECTIVES: To describe three cases of FSFS in cats that become cachectic secondary to different causes without glucocorticoid involvement. To describe the histopathological features of connective tissue for both fragile skin and the skin after healing. RESULTS: All cats developed cachexia in less than two months (body condition score ranging from 1–1.5). Concomitant diseases were diagnosed in Case 1 (aspiration pneumonia due to mega‐oesophagus) and Case 2 (feline immunodeficiency virus (FIV)). In Case 3, malnutrition was suspected as a primary cause. The main histological feature of fragile skin was an atrophic dermis with pale eosinophilic, thin and irregular collagen fibres with numerous red cores observed with Masson's stain. Elastic fibres were normal. Postrecovery histopathological findings at 11 (Case 1) and six months (Case 3) after diagnosis, indicated normalization of the collagen and of the whole skin as compared with controls. CONCLUSIONS AND CLINICAL IMPORTANCE: To the best of the authors’ knowledge, this is the first report describing a reversible, nonsteroid‐induced FSFS, associated with rapidly developing cachexia in cats.
has issue date	2017-05-31(xsd:dateTime)
bibo:doi	10.1111/vde.12457
bibo:pmid	28560784
has license	no-cc
sha1sum (hex)	66867778cf02cd5f3599ccb86376794fbde4a2e9
schema:url	https://doi.org/10.1111/vde.12457
resource representing a document's title	Reversible and cachexia‐associated feline skin fragility syndrome in three cats
has PubMed Central identifier	PMC7169296
has PubMed identifier	28560784
schema:publication	Vet Dermatol
resource representing a document's body	covid:66867778cf02cd5f3599ccb86376794fbde4a2e9#body_text
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