About: Molecular analysis of Idiopathic Subglottic Stenosis for Mycobacterium species: A North American Airway Collaborative (NoAAC) TS-04 study

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Molecular analysis of Idiopathic Subglottic Stenosis for Mycobacterium species: A North American Airway Collaborative (NoAAC) TS-04 study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Molecular analysis of Idiopathic Subglottic Stenosis for Mycobacterium species: A North American Airway Collaborative (NoAAC) TS-04 study
Creator	Drake, Wonder Gelbard, Alexander Jenkins, Kevin Katsantonis, Nicolas-George Mizuta, Masanobu Newcomb, Dawn Rotsinger, Joseph Rousseau, Bernard Stratton, Charles Yang, Liying Francis, David Blackwell, Timothy Daniero, James Edell, Eric Ekbom, Dale Gaddy, Jennifer Garrett, C Hillel, Alexander Kasperbauer, Jan Mcgregor, Tracy Netterville, James Wootten, Christopher
source	Medline; PMC
abstract	RATIONALE: Idiopathic subglottic stenosis (iSGS) is an unexplained obstruction involving the lower laryngeal and upper tracheal airway. Persistent mucosal inflammation is a hallmark of the disease. Epithelial microbiota dysbiosis is found in other chronic inflammatory mucosal diseases; however, the relationship between tracheal microbiota composition and iSGS is unknown. OBJECTIVES: Given the critical role for host defense at mucosal barriers, we analyzed tissue specimens from iSGS patients for the presence of microbial pathogens. METHODS: Utilizing 20 human iSGS, 20 intubation-related tracheal stenosis (iLTS) and 10 healthy control specimens we applied molecular, immunohistochemical, electron microscopic, immunologic and Sanger™ sequencing techniques. MAIN RESULTS: With unbiased culture-independent nucleic acid, protein, and immunologic approaches, we demonstrate that Mycobacterium species are uniquely associated with iSGS. Phylogenetic analysis of the mycobacterial virulence factor rpoB suggests that rather than Mycobacterium Tuberculosis (Mtb), a variant member of the Mycobacterium Tuberculosis Complex (MtbC), or a closely related novel mycobacterium is present in iSGS specimens. CONCLUSIONS: These studies identify a novel pathogenic role for established large airway bacteria, and provide new targets for future therapeutic intervention. LEVEL OF EVIDENCE: NA.
has issue date	2016-06-14(xsd:dateTime)
bibo:doi	10.1002/lary.26097
bibo:pmid	27295947
has license	green-oa
sha1sum (hex)	667716e0a8cc4da6cdf25e628799049fb36db60c
schema:url	https://doi.org/10.1002/lary.26097
resource representing a document's title	Molecular analysis of Idiopathic Subglottic Stenosis for Mycobacterium species: A North American Airway Collaborative (NoAAC) TS-04 study
has PubMed Central identifier	PMC5156582
has PubMed identifier	27295947
schema:publication	The Laryngoscope
resource representing a document's body	covid:667716e0a8cc4da6cdf25e628799049fb36db60c#body_text
is schema:about of	named entity 'involving' named entity 'NORTH AMERICAN' named entity 'INVOLVING' named entity 'MICROBIOTA' named entity 'IS A' named entity 'OBSTRUCTION' named entity 'TRACHEAL' named entity 'AIRWAY' named entity 'MYCOBACTERIUM SPECIES' named entity 'FOUND' named entity 'SUBGLOTTIC STENOSIS' named entity 'ACCESS' named entity 'MOLECULAR ANALYSIS' named entity 'COLLABORATIVE' named entity 'AIRWAY' named entity 'IDIOPATHIC' named entity 'RATIONALE' named entity 'UNKNOWN' named entity 'MUCOSAL INFLAMMATION' named entity 'MUCOSAL' named entity 'LOWER' named entity 'IDIOPATHIC' named entity 'UPPER' named entity 'DISEASES' named entity 'COMPOSITION' named entity 'SUBGLOTTIC STENOSIS' named entity 'INFLAMMATORY' named entity 'PERSISTENT' named entity 'RELATIONSHIP' named entity 'LARYNGEAL' named entity 'CHRONIC' named entity 'PUBLIC' named entity 'STUDY' named entity 'UNEXPLAINED' named entity 'EPITHELIAL' named entity 'DISEASE' named entity 'DYSBIOSIS' named entity 'HHS' named entity 'composition' named entity 'inflammation' named entity 'tracheal' named entity 'microbiota' named entity 'airway' named entity 'mucosal' named entity 'microbiota' named entity 'North American' named entity 'Airway' named entity 'Microbiological' named entity 'IL-23' named entity 'Normal distribution' named entity 'Mycobacterium' named entity 'peripheral blood mononuclear cells' named entity 'microorganisms' named entity 'IL-23' named entity 'mucosa' named entity 'expression levels' named entity 'Valencia, CA' named entity 'protein coding sequence' named entity 'antigenic protein' named entity 'incubation'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software