About: Experimental infection in calves with a specific subtype of verocytotoxin-producing Escherichia coli O157:H7 of bovine origin

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About: Experimental infection in calves with a specific subtype of verocytotoxin-producing Escherichia coli O157:H7 of bovine origin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Experimental infection in calves with a specific subtype of verocytotoxin-producing Escherichia coli O157:H7 of bovine origin
Creator	Aspán, Anna Boqvist, Sofia Eriksson, Erik Jonsson, Malin Urdahl, Anne
source	Medline; PMC
abstract	BACKGROUND: In Sweden, a particular subtype of verocytotoxin-producing Escherichia coli (VTEC) O157:H7, originally defined as being of phage type 4, and carrying two vtx(2 )genes, has been found to cause the majority of reported human infections during the past 15 years, including both sporadic cases and outbreaks. One plausible explanation for this could be that this particular subtype is better adapted to colonise cattle, and thereby may be excreted in greater concentrations and for longer periods than other VTEC O157:H7 subtypes. METHODS: In an experimental study, 4 calves were inoculated with 10(9 )colony forming units (cfu) of strain CCUG 53931, representative of the subtype VTEC O157:H7 (PT4;vtx(2);vtx(2c)). Two un-inoculated calves were co-housed with the inoculated calves. Initially, the VTEC O157:H7 strain had been isolated from a dairy herd with naturally occurring infection and the farm had previously also been linked to human infection with the same strain. Faecal samples were collected over up to a 2-month period and analysed for VTEC O157 by immuno-magnetic separation (IMS), and IMS positive samples were further analysed by direct plating to elucidate the shedding pattern. Samples were also collected from the pharynx. RESULTS: All inoculated calves proved culture-positive in faeces within 24 hours after inoculation and the un-inoculated calves similarly on days 1 and 3 post-inoculation. One calf was persistently culture-positive for 43 days; in the remainder, the VTEC O157:H7 count in faeces decreased over the first 2 weeks. All pharyngeal samples were culture-negative for VTEC O157:H7. CONCLUSION: This study contributes with information concerning the dynamics of a specific subtype of VTEC O157:H7 colonisation in dairy calves. This subtype, VTEC O157:H7 (PT4;vtx(2;)vtx(2c)), is frequently isolated from Swedish cattle and has also been found to cause the majority of reported human infections in Sweden during the past 15 years. In most calves, inoculated with a representative strain of this specific subtype, the numbers of shed bacteria declined over the first two weeks. One calf could possibly be classified as a high-shedder, excreting high levels of the bacterium for a prolonged period.
has issue date	2009-10-31(xsd:dateTime)
bibo:doi	10.1186/1751-0147-51-43
bibo:pmid	19878595
has license	cc-by
sha1sum (hex)	6507acff69dc9963ee7fdffc4a7f4edae0b5f609
schema:url	https://doi.org/10.1186/1751-0147-51-43
resource representing a document's title	Experimental infection in calves with a specific subtype of verocytotoxin-producing Escherichia coli O157:H7 of bovine origin
has PubMed Central identifier	PMC2776595
has PubMed identifier	19878595
schema:publication	Acta Vet Scand
resource representing a document's body	covid:6507acff69dc9963ee7fdffc4a7f4edae0b5f609#body_text
is schema:about of	named entity 'colonise' named entity 'Escherichia coli O157' named entity 'bovine' named entity 'BOVINE' named entity 'SWEDEN' named entity 'CONCENTRATIONS' named entity 'OUTBREAKS' named entity 'VEROCYTOTOXIN' named entity 'INCLUDING' named entity 'INFECTIONS' named entity 'ADAPTED' named entity 'FOUND' named entity 'REPORTED' named entity 'COULD BE' named entity 'CAUSE' named entity 'SUBTYPE' named entity 'TYPE 4' named entity 'PAST' named entity 'VTEC' named entity 'PRODUCING' named entity 'EXPERIMENTAL INFECTION' named entity 'YEARS' named entity 'MAJORITY' named entity 'EXPLANATION' named entity 'ESCHERICHIA COLI' named entity 'PRODUCING' named entity 'VEROCYTOTOXIN' named entity 'SPECIFIC' named entity 'ACTA' named entity 'SUBTYPE' named entity 'CATTLE' named entity 'GENES' named entity 'HUMAN' named entity 'PHAGE TYPE' named entity 'CARRYING' named entity 'O157' named entity 'BEING' named entity 'ORIGIN' named entity 'ESCHERICHIA COLI O157' named entity 'GREATER' named entity 'BETTER' named entity 'CALVES' named entity 'DEFINED' named entity 'PERIODS' named entity 'PARTICULAR' covid:arg/6507acff69dc9963ee7fdffc4a7f4edae0b5f609 named entity 'O157' named entity 'adapted' named entity 'Experimental' named entity 'O157:H7' named entity 'O157:H7' named entity 'Escherichia coli' named entity 'VTEC' named entity 'VTEC' named entity 'infection' named entity 'O157:H7' named entity 'beef' named entity 'VTEC' named entity 'lettuce' named entity 'rotavirus' named entity 'O157:H7' named entity 'enterohaemorrhagic' named entity 'dairy calves' named entity 'Faecal samples' named entity 'O157:H7' named entity 'O157:H7' named entity 'cattle' named entity 'XbaI' named entity 'inoculation' named entity 'VTEC' named entity 'VTEC' named entity 'oral administration' named entity 'shedder' named entity 'Sweden' named entity 'risk factor' named entity 'dairy calves' named entity 'body weight'

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