About: New Insights of an Old Defense System: Structure, Function, and Clinical Relevance of the Complement System

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	New Insights of an Old Defense System: Structure, Function, and Clinical Relevance of the Complement System
Creator	Huber-Lang, Markus Gebhard, Florian Ehrnthaller, Christian Ignatius, Anita
Source	PMC
abstract	The complement system was discovered a century ago as a potent defense cascade of innate immunity. After its first description, continuous experimental and clinical research was performed, and three canonical pathways of activation were established. Upon activation by traumatic or surgical tissue damage, complement reveals beneficial functions of pathogen and danger defense by sensing and clearing injured cells. However, the latest research efforts have provided a more distinct insight into the complement system and its clinical subsequences. Complement has been shown to play a significant role in the pathogenesis of various inflammatory processes such as sepsis, multiorgan dysfunction, ischemia/reperfusion, cardiovascular diseases and many others. The three well-known activation pathways of the complement system have been challenged by newer findings that demonstrate direct production of central complement effectors (for example, C5a) by serine proteases of the coagulation cascade. In particular, thrombin is capable of producing C5a, which not only plays a decisive role on pathogens and infected/damaged tissues, but also acts systemically. In the case of uncontrolled complement activation, “friendly fire” is generated, resulting in the destruction of healthy host tissue. Therefore, the traditional research that focuses on a mainly positive-acting cascade has now shifted to the negative effects and how tissue damage originated by the activation of the complement can be contained. In a translational approach including structure-function relations of this ancient defense system, this review provides new insights of complement-mediated clinical relevant diseases and the development of complement modulation strategies and current research aspects.
has issue date	2010-10-29(xsd:dateTime)
bibo:doi	10.2119/molmed.2010.00149
bibo:pmid	21046060
has license	no-cc
sha1sum (hex)	64e1170eeb4f949a59dc09e714609a5c36c4122f
schema:url	https://doi.org/10.2119/molmed.2010.00149
resource representing a document's title	New Insights of an Old Defense System: Structure, Function, and Clinical Relevance of the Complement System
has PubMed Central identifier	PMC3060978
has PubMed identifier	21046060
schema:publication	Mol Med
resource representing a document's body	covid:64e1170eeb4f949a59dc09e714609a5c36c4122f#body_text
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