About: Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases

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About: Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases
Creator	Ni, Li Zhang, Xin Huang, Wei Wang, Hong Wang, Z Li, C Zhang, L Zhou, Ning Wang, H Huang, W Li, Chenze Wang, Dao-Wen Wang, Zhiquan Jiang, Jiangang Ni, J Zhou, N
Source	Medline; PMC
abstract	Coronavirus disease 2019 (COVID-19) is a global pandemic which has caused numerous deaths worldwide. The present study investigated the roles of hypoproteinemia in the clinical outcome and liver dysfunction of COVID-19 patients. In this retrospective study, we extracted data from 2,623 clinically confirmed adult COVID-19 patients (>18 years old) between January 29, 2020 and March 6, 2020 in Tongji Hospital, Wuhan, China. The patients were divided into three groups—non-critically ill, critically ill, and death groups—in accordance with the Chinese Clinical Guideline for COVID-19. Serum albumin, low-density lipoproteins cholesterol (LDL-C), and high-density lipoproteins cholesterol (HDL-C) concentrations and inflammatory cytokines levels were measured and compared among these three groups. The median age of these 2,623 patients was 64 years old (interquartile range (IQR), 52–71). Among the patients enrolled in the study, 2,008 (76.6%) were diagnosed as non-critically ill and 615 (23.4%) were critically ill patients, including 383 (14.6%) critically ill survivors and 232 (8.8%) critically ill deaths in the hospital. Marked hypoalbuminemia occurred in 38.2%, 71.2%, and 82.4% patients in non-critically ill, critically ill, and death groups, respectively, on admission and 45.9%, 77.7%, and 95.6% of these three groups, respectively, during hospitalization. We also discovered that serum low-density lipoprotein (LDL) and HDL levels were significantly lower in critically ill and death groups compared to non-critically ill group. Meanwhile, the patients displayed dramatically elevated levels of serum inflammatory factors, while a markedly prolonged activated partial thromboplastin time (APTT) in critically ill patients reflected coagulopathy. This study suggests that COVID-19-induced cytokine storm causes hepatotoxicity and subsequently critical hypoalbuminemia, which are associated with exacerbation of disease-associated inflammatory responses and progression of the disease and ultimately leads to death for some critically ill patients. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material is available for this article at 10.1007/s11427-020-1733-4 and is accessible for authorized users.
has issue date	2020-06-18(xsd:dateTime)
bibo:doi	10.1007/s11427-020-1733-4
bibo:pmid	32567003
has license	no-cc
sha1sum (hex)	64cc6484ae625c074dd39b6ad0ed2cb92a0fcf7e
schema:url	https://doi.org/10.1007/s11427-020-1733-4
resource representing a document's title	Decreased serum albumin level indicates poor prognosis of COVID-19 patients: hepatic injury analysis from 2,623 hospitalized cases
has PubMed Central identifier	PMC7306450
has PubMed identifier	32567003
schema:publication	Sci China Life Sci
resource representing a document's body	covid:64cc6484ae625c074dd39b6ad0ed2cb92a0fcf7e#body_text
is schema:about of	named entity 'critically ill' named entity 'hypoalbuminemia' named entity 'disease' named entity 'The' named entity 'HDL-C' named entity 'Marked' named entity 'low-density lipoproteins' named entity 'critically ill' named entity 'patients' named entity 'patients' named entity 'patients' named entity 'APTT' named entity 'measured' named entity 'hospital' named entity 'activated partial thromboplastin time' named entity 'coagulopathy' named entity 'cytokine storm' named entity 'groups' named entity 'critically ill' named entity 'groups' named entity 'COVID-19' named entity 'critically ill' named entity 'hypoalbuminemia' named entity 'HDL-C' named entity 'critically ill' named entity 'serum' named entity 'Serum albumin' named entity 'APTT' named entity 'Clinical Guideline' named entity 'cholesterol' named entity 'coagulopathy' named entity 'critically ill' named entity 'inflammatory factors' named entity 'COVID-19' named entity 'critically ill' named entity 'serum' named entity 'interquartile range' named entity 'high-density lipoproteins' named entity 'hypoalbuminemia' named entity 'prognosis' named entity 'inflammatory responses' named entity 'LDL-C' named entity 'critically ill patients' named entity '615' named entity 'ill' named entity 'group' named entity 'low-density lipoprotein' named entity 'critically ill' named entity 'DURING HOSPITALIZATION' named entity 'ASSOCIATED' named entity 'CONCENTRATIONS' named entity 'PROLONGED ACTIVATED PARTIAL THROMBOPLASTIN TIME' named entity 'critically ill patients' named entity 'HDL' named entity 'critically ill' named entity 'cholesterol' named entity 'inflammatory cytokines' named entity 'LDL' named entity 'activated partial thromboplastin time' named entity 'COVID-19' named entity 'critically ill patients' named entity 'hepatic injury' named entity 'hepatotoxicity' named entity 'COVID-19' covid:arg/64cc6484ae625c074dd39b6ad0ed2cb92a0fcf7e named entity 'serum albumin'

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