About: First detection of neboviruses in yak (Bos grunniens) and identification of a novel neboviruses based on complete genome

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About: First detection of neboviruses in yak (Bos grunniens) and identification of a novel neboviruses based on complete genome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	First detection of neboviruses in yak (Bos grunniens) and identification of a novel neboviruses based on complete genome
Creator	Tang, Cheng Yue, Hua Zhang, Bin Guo, Zijing He, Qifu
Source	Elsevier; Medline; PMC
abstract	Neboviruses (NeVs) is an important causative agent of calf diarrhea. Here, 354 diarrhoeic samples were collected from yak on 55 farms in the Qinghai-Tibet Plateau, China. 22.0% of the diarrhoeic samples were detected as NeVs-positive by RT–PCR assay. Phylogenetic analysis of 78 NeVs RdRp fragments showed that 69 strains were closely related to NB-like strains, and the remaining 9 strains were clustered into an independent branch, which may represent a novel RdRp genotype. Two complete NeVs genomes (YAK/NRG-17/17/CH and YAK/HY1-2/18/CH) were successfully sequenced with 7459 nt and 7460 nt in length, respectively. The genomes of the two strains only shared 68.1%–69.3% nt identity with all six known NeVs genomes, and phylogenetic trees based on its genome, VP1, RdRp, VP2, P34, NTPase, P30, VPg and 3CLpro proteins suggested that the two strains may represent a novel NeVs strain with novel VP1 genotype and novel RdRp genotype. Notably, 11.5% NeVs strains were screened as the novel NeVs strains based VP1 and RdRp sequences. These novel NeVs strains were detected from 6 farms in two counties, indicating that the novel NeVs has spread in local region. To best of our knowledge, this is the first detection of NeVs in yak. Moreover, a novel NeVs strain was identified based on complete genome. These results contribute to further understand the prevalence and genetic evolution of NeVs.
has issue date	2019-08-09(xsd:dateTime)
bibo:doi	10.1016/j.vetmic.2019.108388
bibo:pmid	31500726
has license	no-cc
sha1sum (hex)	64910e72cdeca0bc91eb53df91d0a5a48a0da5d5
schema:url	https://doi.org/10.1016/j.vetmic.2019.108388
resource representing a document's title	First detection of neboviruses in yak (Bos grunniens) and identification of a novel neboviruses based on complete genome
has PubMed Central identifier	PMC7127790
has PubMed identifier	31500726
schema:publication	Vet Microbiol
resource representing a document's body	covid:64910e72cdeca0bc91eb53df91d0a5a48a0da5d5#body_text
is schema:about of	named entity 'RdRp' named entity 'based' named entity 'VP1' named entity 'complete' named entity 'strains' named entity 'NeVs' named entity 'calf' named entity 'NOVEL' named entity 'SPREAD' named entity 'NTPASE' named entity 'REMAINING' named entity 'CONTRIBUTE ' named entity 'KNOWLEDGE' named entity 'HERE' named entity 'CHINA' named entity 'ITS' named entity 'COLLECTED' named entity 'RELATED' named entity 'FARMS' named entity 'SHARED' named entity 'PREVALENCE' named entity 'DIARRHEA' named entity 'KNOWN' named entity 'PROTEINS' named entity 'VP2' covid:arg/64910e72cdeca0bc91eb53df91d0a5a48a0da5d5 named entity 'OUR' named entity 'LENGTH' named entity 'LIKE' named entity 'LOCAL' named entity 'GENOMES' named entity 'P30' named entity 'BRANCH' named entity 'DETECTION' named entity 'GENETIC' named entity 'CLUSTERED' named entity 'EVOLUTION' named entity 'COMPLETE' named entity 'BEST' named entity 'REGION' named entity 'VP1' named entity 'FRAGMENTS' named entity 'VPG' named entity 'RT-PCR ASSAY' named entity 'THESE' named entity 'CAUSATIVE AGENT' named entity 'IDENTITY' named entity 'TREES' named entity 'YAK' named entity 'RESULTS' named entity 'CALF' named entity '11.5' named entity 'GENOTYPE' named entity 'REPRESENT' named entity 'IDENTIFICATION' named entity 'YAK' named entity 'BASED' named entity 'TIBET' named entity 'PHYLOGENETIC ANALYSIS' named entity 'P34' named entity 'IDENTIFIED' named entity 'RDRP' named entity 'POSITIVE' named entity 'COUNTIES' named entity 'INDICATING' named entity 'UNDERSTAND' named entity 'IMPORTANT' named entity 'STRAIN' named entity 'DETECTED' named entity 'GENOME' named entity 'SAMPLES' named entity 'PLATEAU' named entity 'BASED' named entity 'COMPLETE' named entity 'DETECTION' named entity 'STRAINS' named entity 'NOVEL'

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