About: The evolving world of protein-G-quadruplex recognition: A medicinal chemist’s perspective

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The evolving world of protein-G-quadruplex recognition: A medicinal chemist’s perspective
Creator	Gatto, Barbara Palumbo, Manlio Sissi, Claudia
Source	Elsevier; Medline; PMC
abstract	Abstract The physiological and pharmacological role of nucleic acids structures folded into the non canonical G-quadruplex conformation have recently emerged. Their activities are targeted at vital cellular processes including telomere maintenance, regulation of transcription and processing of the pre-messenger or telomeric RNA. In addition, severe conditions like cancer, fragile X syndrome, Bloom syndrome, Werner syndrome and Fanconi anemia J are related to genomic defects that involve G-quadruplex forming sequences. In this connection G-quadruplex recognition and processing by nucleic acid directed proteins and enzymes represents a key event to activate or deactivate physiological or pathological pathways. In this review we examine protein-G-quadruplex recognition in physiologically significant conditions and discuss how to possibly exploit the interactions’ selectivity for targeted therapeutic intervention.
has issue date	2011-08-31(xsd:dateTime)
bibo:doi	10.1016/j.biochi.2011.04.018
bibo:pmid	21549174
has license	els-covid
sha1sum (hex)	648294ddaa0f2eacd9f760b458b023827f398045
schema:url	https://doi.org/10.1016/j.biochi.2011.04.018
resource representing a document's title	The evolving world of protein-G-quadruplex recognition: A medicinal chemist’s perspective
has PubMed Central identifier	PMC7126356
has PubMed identifier	21549174
schema:publication	Biochimie
resource representing a document's body	covid:648294ddaa0f2eacd9f760b458b023827f398045#body_text
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