About: Microbiology of Bronchoalveolar Lavage Fluid in Children With Acute Nonresponding or Recurrent Community-Acquired Pneumonia: Identification of Nontypeable Haemophilus influenzae as a Major Pathogen

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Microbiology of Bronchoalveolar Lavage Fluid in Children With Acute Nonresponding or Recurrent Community-Acquired Pneumonia: Identification of Nontypeable Haemophilus influenzae as a Major Pathogen Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Microbiology of Bronchoalveolar Lavage Fluid in Children With Acute Nonresponding or Recurrent Community-Acquired Pneumonia: Identification of Nontypeable Haemophilus influenzae as a Major Pathogen
Creator	De Schutter, Iris Malfroot, Anne Soetens, Oriane Verhaegen, Jan De Wachter, Elke Pié, Denis Xoise Crokaert, Franc
Source	Medline; PMC
abstract	Background. Precise etiologic diagnosis in pediatric community-acquired pneumonia (CAP) remains challenging. Methods. We conducted a retrospective study of CAP etiology in 2 groups of pediatric patients who underwent flexible bronchoscopy (FOB) with bronchoalveolar lavage (BAL); children with acute nonresponsive CAP (NR-CAP; n = 127) or recurrent CAP (Rec-CAP; n = 123). Procedural measures were taken to limit contamination risk and quantitative bacterial culture of BAL fluid (significance cutoff point, ≥10(4) colony-forming units/mL) was used. Blood culture results, serological test results, nasopharyngeal secretion findings, and pleural fluid culture results were also assessed, where available. Results. An infectious agent was detected in 76.0% of cases. In 51.2% of infections, aerobic bacteria were isolated, of which 75.0%, 28.9%, and 13.3% were Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae, respectively. Most (97.9%) of the H. influenzae strains were nontypeable (NTHi). H. influenzae was detected in 26.0% of NR-CAP cases and 51.2% of Rec-CAP cases, whereas Mycoplasma pneumoniae was the predominant pathogen in the NR-CAP group (accounting for 34.9% of cases) but not in the Rec-CAP group (19.3%). Viruses were found in 30.4% of cases, with respiratory syncytial virus, parainfluenzaviruses, and influenzaviruses detected most frequently. Mixed infections were found in 18.9% of NR-CAP cases and 30.1% of Rec-CAP cases. Conclusions. A variety of microorganisms were isolated with frequent mixed infection. NTHi was one of the major pathogens found, especially in association with recurrent CAP, possibly because of improved detection with the FOB with BAL procedure. This suggests that the burden of pediatric CAP could be reduced by addressing NTHi as a major causative pathogen.
has issue date	2011-06-15(xsd:dateTime)
bibo:doi	10.1093/cid/cir235
bibo:pmid	21628484
has license	no-cc
sha1sum (hex)	646e1563272926efc0d7100555511eb7b4b98aa6
schema:url	https://doi.org/10.1093/cid/cir235
resource representing a document's title	Microbiology of Bronchoalveolar Lavage Fluid in Children With Acute Nonresponding or Recurrent Community-Acquired Pneumonia: Identification of Nontypeable Haemophilus influenzae as a Major Pathogen
has PubMed Central identifier	PMC7107807
has PubMed identifier	21628484
schema:publication	Clin Infect Dis
resource representing a document's body	covid:646e1563272926efc0d7100555511eb7b4b98aa6#body_text
is schema:about of	named entity 'MICROBIOLOGY' named entity 'Haemophilus influenzae' named entity 'Pathogen' named entity 'ACUTE' named entity 'BACKGROUND' named entity 'RECURRENT' named entity 'PATHOGEN' named entity 'A MAJOR' named entity 'NONTYPEABLE HAEMOPHILUS INFLUENZAE' named entity 'IDENTIFICATION' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'CHILDREN' named entity 'DIAGNOSIS' named entity 'PEDIATRIC' named entity 'COMMUNITY-ACQUIRED PNEUMONIA' named entity 'BRONCHOALVEOLAR LAVAGE FLUID' named entity 'PRECISE' covid:arg/646e1563272926efc0d7100555511eb7b4b98aa6 named entity 'community-acquired pneumonia' named entity 'Background' named entity 'community-acquired pneumonia' named entity 'pediatric' named entity 'Pathogen' named entity 'Microbiology' named entity 'developed countries' named entity 'b-lactamase' named entity 'NTHi' named entity 'PCR' named entity 'flexible fiberoptic bronchoscope' named entity 'pathogen' named entity 'S. aureus' named entity 'Flexible bronchoscopy' named entity 'RSV' named entity 'infectious agent' named entity 'flexible bronchoscope' named entity 'European Respiratory Society' named entity 'viruses' named entity 'M. catarrhalis' named entity 'cystic fibrosis' named entity 'pneumococcal vaccination' named entity 'NTHi' named entity 'lung' named entity 'Viral' named entity 'pediatric' named entity 'ampicillin' named entity 'coinfection' named entity 'pleural effusion' named entity 'pathogen' named entity 'LRT' named entity '5.6' named entity 'body weight' named entity 'pneumonia' named entity 'antibiotic susceptibility' named entity 'bacterial infection' named entity 'aerobic bacteria' named entity 'H. influenzae' named entity 'PCR' named entity 'sex ratio' named entity 'clinical practice' named entity 'MIC' named entity 'NTHi' named entity 'bacteremia' named entity 'Viruses' named entity 'infection' named entity 'macrolides' named entity 'pleural fluid' named entity 'pathogens' named entity 'assay' named entity 'pleural fluid' named entity 'bacterial pathogens' named entity 'minimum inhibitory concentration' named entity 'Mycoplasma pneumoniae' named entity 'H. influenzae' named entity 'ethics committee' named entity 'AOM'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software