About: Accuracy and reproducibility of low-dose submillisievert chest CT for the diagnosis of COVID-19

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About: Accuracy and reproducibility of low-dose submillisievert chest CT for the diagnosis of COVID-19 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Accuracy and reproducibility of low-dose submillisievert chest CT for the diagnosis of COVID-19
Creator	Ranst, Marc Frans, Johan Symons, Rolf Dangis, Anthony De Bruecker, Yves Demeyere, Annick Gieraerts, Christopher Gillis, Marc Janssen, Lode Obbels, Dagmar Valgaeren, Hanne
Source	PMC
abstract	PURPOSE: To demonstrate the accuracy and reproducibility of low-dose submillisievert chest CT for the diagnosis of COVID-19 infection in emergency room (ER) patients. MATERIALS AND METHODS: This was a HIPAA-compliant, institutional review board-approved retrospective study. From March 14(th) to March 24(th) 2020, 192 ER patients with symptoms suggestive of COVID-19 infection were studied with low-dose chest CT and real time polymerase chain reaction (RT-PCR). Image analysis included likelihood of COVID-19 infection and semi-quantitative extent of lung involvement. CT images were analyzed by 2 radiologists blinded to RT-PCR results. Reproducibility was assessed with McNemar test and intra-class correlation coefficient (ICC). Time between CT acquisition and report was measured. RESULTS: When compared to RT-PCR, low-dose submillisievert chest CT demonstrated excellent sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for diagnosis of COVID-19 (86.7%, 93.6%, 91.1%, 90.3%, and 90.2%, respectively), in particular in patients with clinical symptoms for >48h (95.6%, 93.2%, 91.5%, 96.5%, and 94.4%, respectively). In patients with a positive CT, likelihood of disease increased from 43.2% (pre-test probability) to 91.1% or 91.4% (post-test probability), while in patients with a negative CT, likelihood of disease decreased to 9.6% or 3.7% for all patients or those with clinical symptoms for >48h, respectively. The prevalence of alternative diagnoses based on chest CT in patients without COVID-19 infection was 17.6%. Mean effective radiation dose was 0.56±0.25 mSv (SD). Median time between CT acquisition and report was 25 minutes (IQR: 13-49 minutes). Intra- and interreader reproducibility of CT was excellent (all ICC□0.95) without significant bias in Bland-Altman analysis. CONCLUSION: Low-dose submillisievert chest CT allows for rapid, accurate and reproducible assessment of COVID-19 infection in ER patients, in particular in patients with symptoms lasting longer than 48 hours. Chest CT has the additional advantage of offering alternative diagnoses in a significant subset of patients.
has issue date	2020-04-21(xsd:dateTime)
bibo:doi	10.1148/ryct.2020200196
has license	no-cc
sha1sum (hex)	645d90a2a3a2a84eb92a7357c0a7fe53c7cf6704
schema:url	https://doi.org/10.1148/ryct.2020200196
resource representing a document's title	Accuracy and reproducibility of low-dose submillisievert chest CT for the diagnosis of COVID-19
has PubMed Central identifier	PMC7233439
schema:publication	Radiol Cardiothorac Imaging
resource representing a document's body	covid:645d90a2a3a2a84eb92a7357c0a7fe53c7cf6704#body_text
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