About: Critical role of cellular cholesterol in bovine rotavirus infection

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About: Critical role of cellular cholesterol in bovine rotavirus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Critical role of cellular cholesterol in bovine rotavirus infection
Creator	Su, Shuo Li, Shoujun Cui, Jin Chen, Yao Xie, Jiexiong Fu, Xinliang Gao, Ming Hong, Malin
Source	Medline; PMC
abstract	BACKGROUND: Bovine rotavirus (BRV) is a non-enveloped dsRNA virus that cause neonatal calf diarrhea. Lipid rafts are cholesterol-enrich membrane mircodomains that play a vital role in many cellular processes. In this study, the effect of cellular cholesterol depletion on infection of MA-104 cells with bovine rotavirus was investigated. RESULTS: We demonstrated that cholesterol depletion of the plasma membrane by MβCD had no effect on BRV binding to cells but significantly impaired BRV entry in a dose-dependent manner and the effect was partially reversed by addition of exogenous cholesterol, suggesting the reduction of BRV infection by MβCD was specifically due to cholesterol depletion. Cholesterol depletion after virus entry did not reduce BRV replication, whereas affected virus assembly. CONCLUSIONS: Taken together, our results demonstrate that cell membrane cholesterol is essential to BRV infectivity.
has issue date	2014-05-23(xsd:dateTime)
bibo:doi	10.1186/1743-422x-11-98
bibo:pmid	24884772
has license	cc-by
sha1sum (hex)	63f9ef8701b8b68aab585d81fa58bd567ade8e4a
schema:url	https://doi.org/10.1186/1743-422x-11-98
resource representing a document's title	Critical role of cellular cholesterol in bovine rotavirus infection
has PubMed Central identifier	PMC4053397
has PubMed identifier	24884772
schema:publication	Virol J
resource representing a document's body	covid:63f9ef8701b8b68aab585d81fa58bd567ade8e4a#body_text
is schema:about of	covid:arg/63f9ef8701b8b68aab585d81fa58bd567ade8e4a named entity 'INVESTIGATED' named entity 'INFECTION' named entity 'NEONATAL CALF DIARRHEA' named entity 'CAUSE' named entity 'CELLULAR' named entity 'ENRICH' named entity 'LIPID RAFTS' named entity 'BACKGROUND' named entity 'IS A' named entity 'CHOLESTEROL DEPLETION' named entity 'ROLE' named entity 'BOVINE ROTAVIRUS' named entity 'VITAL' named entity 'ROLE' named entity 'PLAY' named entity 'CELLULAR' named entity 'CRITICAL' named entity 'BOVINE ROTAVIRUS' named entity 'NON-ENVELOPED DSRNA VIRUS' named entity 'STUDY' named entity 'ROTAVIRUS INFECTION' named entity 'CELLULAR PROCESSES' named entity 'MEMBRANE' named entity 'CHOLESTEROL' named entity 'CELLS' named entity 'CHOLESTEROL' named entity '104' named entity 'EFFECT' named entity 'cholesterol' named entity 'Life Technologies' named entity 'infection' named entity 'virus' named entity 'DMEM' named entity 'Thermo Scientific' named entity 'glycosylphosphatidylinositol' named entity 'critical role' named entity 'SDS-PAGE' named entity 'GraphPad Prism' named entity 'statistical significant' named entity 'protein kinases' named entity 'MβCD' named entity 'lipid' named entity 'cattle' named entity 'infection' named entity 'newborn calves' named entity 'lipid rafts' named entity 'virus entry' named entity 'signal transduction' named entity 'canine distemper virus' named entity '37°C' named entity 'SYBR' named entity 'cholesterol' named entity 'Laemmli' named entity 'multiplicity of infection' named entity 'cholesterol depletion' named entity 'cholesterol' named entity 'cholesterol depletion' named entity 'primer' named entity 'Amplex' named entity 'membrane microdomains' named entity 'cholesterol' named entity 'Bio-Rad' named entity 'PBS' named entity '37°C' named entity 'MβCD' named entity 'virus' named entity 'MβCD' named entity 'cellular membrane' named entity 'plasma membrane' named entity 'optical density' named entity '37°C' named entity 'cellular membranes' named entity 'cell lysates'

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