About: Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice

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About: Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice
Creator	Henrissat, Bernard Torralba, Manolito Suchodolski, Jan Nelson, Karen Barry, Kathleen Coutinho, Pedro Dowd, Scot Fahey, George Ko Cann, Isaac Middelbos, Ingmar Swanson, Kelly Vester, Brittany White, Bryan
Source	Medline; PMC
abstract	This study is the first to use a metagenomics approach to characterize the phylogeny and functional capacity of the canine gastrointestinal microbiome. Six healthy adult dogs were used in a crossover design and fed a low-fiber control diet (K9C) or one containing 7.5% beet pulp (K9BP). Pooled fecal DNA samples from each treatment were subjected to 454 pyrosequencing, generating 503 280 (K9C) and 505 061 (K9BP) sequences. Dominant bacterial phyla included the Bacteroidetes/Chlorobi group and Firmicutes, both of which comprised ∼35% of all sequences, followed by Proteobacteria (13–15%) and Fusobacteria (7–8%). K9C had a greater percentage of Bacteroidetes, Fusobacteria and Proteobacteria, whereas K9BP had greater proportions of the Bacteroidetes/Chlorobi group and Firmicutes. Archaea were not altered by diet and represented ∼1% of all sequences. All archaea were members of Crenarchaeota and Euryarchaeota, with methanogens being the most abundant and diverse. Three fungi phylotypes were present in K9C, but none in K9BP. Less than 0.4% of sequences were of viral origin, with >99% of them associated with bacteriophages. Primary functional categories were not significantly affected by diet and were associated with carbohydrates; protein metabolism; DNA metabolism; cofactors, vitamins, prosthetic groups and pigments; amino acids and derivatives; cell wall and capsule; and virulence. Hierarchical clustering of several gastrointestinal metagenomes demonstrated phylogenetic and metabolic similarity between dogs, humans and mice. More research is required to provide deeper coverage of the canine microbiome, evaluate effects of age, genetics or environment on its composition and activity, and identify its role in gastrointestinal disease.
has issue date	2010-10-21(xsd:dateTime)
bibo:doi	10.1038/ismej.2010.162
bibo:pmid	20962874
has license	bronze-oa
sha1sum (hex)	63893949a0a5e274be628b4f0678c48012fb12f2
schema:url	https://doi.org/10.1038/ismej.2010.162
resource representing a document's title	Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice
has PubMed Central identifier	PMC3105739
has PubMed identifier	20962874
schema:publication	The ISME Journal
resource representing a document's body	covid:63893949a0a5e274be628b4f0678c48012fb12f2#body_text
is schema:about of	named entity 'HUMANS' named entity 'provide' named entity 'group' named entity 'represented' named entity 'proportions' named entity 'Fusobacteria' named entity 'Six' named entity 'amino acids' named entity 'GENE' named entity 'INTERACTIONS' named entity 'GASTROINTESTINAL MICROBIOME' named entity 'CONTAINING' named entity 'ASSOCIATED WITH' named entity 'PRESENT' named entity 'APPROACH' named entity 'EFFECTS' named entity 'DEMONSTRATED' named entity 'VIRAL' named entity 'BUT' named entity 'CRENARCHAEOTA' named entity 'BEET PULP' named entity 'IDENTIFY' named entity 'METABOLIC' named entity 'GENERATING' named entity 'FED' named entity 'BEING' named entity 'B35' named entity 'SAMPLES' named entity 'MICROBIOME' named entity 'PRIMARY' named entity 'PYROSEQUENCING' named entity 'BACTERIAL' named entity 'COMPOSITION' named entity 'ABUNDANT' named entity 'CARBOHYDRATES' named entity 'STUDY' named entity 'EURYARCHAEOTA' named entity 'TO CHARACTERIZE' named entity 'DOMINANT' named entity 'ORIGIN' named entity 'ACTIVITY' named entity 'CONTROL' named entity 'CELL WALL' named entity 'MEMBERS' named entity 'MICE' named entity 'GASTROINTESTINAL' named entity 'SUBJECT' named entity 'CATEGORY' named entity 'METAGENOMICS' named entity 'GENETICS' covid:arg/63893949a0a5e274be628b4f0678c48012fb12f2 named entity 'PIGMENTS' named entity 'PROTEIN METABOLISM' named entity 'ROLE' named entity 'TREATMENT' named entity 'LOW' named entity '0.4' named entity 'COFACTORS' named entity 'DOGS' named entity 'TO PROVIDE' named entity 'VIRULENCE' named entity '287' named entity 'AGE' named entity 'PROTEOBACTERIA' named entity 'PHYLOGENY' named entity '499' named entity 'HUMANS' named entity 'CROSSOVER DESIGN' named entity 'FIRMICUTES'

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