About: The putative protein 6 of the severe acute respiratory syndrome-associated coronavirus: Expression and functional characterization

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	The putative protein 6 of the severe acute respiratory syndrome-associated coronavirus: Expression and functional characterization
Creator	Geng, Hua Ho, Yuan-Yuan Au, Deborah Mun-Yee Chan, Wai-Sing Liu, Yuet-Man Lo, Wing-Ip Waye, Miu-Yee
source	Elsevier; Medline; PMC
abstract	Abstract The SARS-CoV open reading frame 6 (ORF6) is transcribed into mRNA6 and encodes a putative 7.5kDa accessory protein, SARS 6, with unknown function. In this study, we have confirmed the SARS 6 protein expression in lung and intestine tissues of the SARS patients and in SARS-CoV infected Vero E6 cells by immunohistochemistry. Further studies by immunoblot and confocal microscopy analyses revealed the expression and the endoplasmic reticulum (ER) localization of the recombinant SARS 6 protein in mammalian cells. Expression of SARS 6 protein in mammalian cells elicits biological activity of stimulating cellular DNA synthesis.
has issue date	2005-12-19(xsd:dateTime)
bibo:doi	10.1016/j.febslet.2005.11.007
bibo:pmid	16310783
has license	els-covid
sha1sum (hex)	6383845f6a1091d5ae9b77e37fcc679a974ee374
schema:url	https://doi.org/10.1016/j.febslet.2005.11.007
resource representing a document's title	The putative protein 6 of the severe acute respiratory syndrome-associated coronavirus: Expression and functional characterization
has PubMed Central identifier	PMC7094358
has PubMed identifier	16310783
schema:publication	FEBS Letters
resource representing a document's body	covid:6383845f6a1091d5ae9b77e37fcc679a974ee374#body_text
is schema:about of	named entity 'FUNCTIONAL' named entity 'studies' named entity 'open reading frame' named entity 'PROTEIN EXPRESSION' named entity '7.5' named entity 'IMMUNOBLOT' named entity 'INTESTINE' named entity 'OPEN READING FRAME' named entity 'STIMULATING' named entity 'CONFIRMED' named entity 'CELLS' named entity 'RECOMBINANT' named entity 'ELICITS' named entity 'REVEALED' named entity 'TISSUES' named entity 'PROTEIN ' named entity 'PROTEIN ' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'IMMUNOHISTOCHEMISTRY' named entity 'KDA' named entity 'SARS-COV' named entity 'MAMMALIAN' named entity 'BIOLOGICAL ACTIVITY' named entity 'LOCALIZATION' named entity 'SARS' named entity 'ASSOCIATED' named entity 'CORONAVIRUS' named entity 'EXPRESSION' named entity 'CHARACTERIZATION' named entity 'TRANSCRIBED' named entity 'DNA SYNTHESIS' named entity 'CELLULAR' named entity 'STUDY' named entity 'ACCESSORY PROTEIN' named entity 'EXPRESSION' named entity 'HAVE' named entity 'FUNCTION' named entity 'ENDOPLASMIC RETICULUM' named entity 'UNKNOWN' named entity 'LUNG' named entity 'VERO' named entity 'INFECTED' named entity 'PATIENTS' named entity 'STUDIES' named entity 'CONFOCAL MICROSCOPY' covid:arg/6383845f6a1091d5ae9b77e37fcc679a974ee374 named entity 'protein' named entity 'patients' named entity 'confirmed' named entity 'expression' named entity 'kDa' named entity 'SARS-CoV' named entity 'kDa' named entity 'confocal microscopy' named entity 'DNA synthesis' named entity 'mammalian cells' named entity 'SARS-CoV' named entity 'unknown function' named entity 'endoplasmic reticulum' named entity 'mammalian cells' named entity 'intestine' named entity 'mortality rate' named entity 'lysed' named entity 'protein' named entity 'human T-lymphotropic virus' named entity 'Vero E6' named entity 'antibody' named entity 'confocal microscope' named entity 'EGFP' named entity 'CHO' named entity 'lung' named entity 'SARS' named entity 'protein' named entity 'St. Louis' named entity 'SARS'

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