About: Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease

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About: Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease
Creator	Levin, M Banner, C Betts, H Callaghan, M Faust, S Haralambous, E Kroll, J Kwiatkowski, D Maiden, Mcj Pollard, A Rockett, K
Source	Medline; PMC
abstract	Adhesion between the opacity-associated adhesin (Opa) proteins of Neisseria meningitidis and human carcino-embryonic antigen cell adhesion molecule (CEACAM) proteins is an important stage in the pathogenesis of meningococcal disease, a globally important bacterial infection. Most disease is caused by a small number of meningococcal genotypes known as hyperinvasive lineages. As these are also carried asymptomatically, acquisition of them alone cannot explain why only some hosts develop meningococcal disease. Our aim was to determine whether genetic diversity in CEACAM is associated with susceptibility to meningococcal disease. Frequency distributions of alleles, genotypes and haplotypes were compared in four CEACAM genes in 384 case samples and 190 controls. Linkage disequilibrium among polymorphic sites, haplotype structures and relationships were also analysed. A number of polymorphisms were observed in CEACAM genes but the diversity of CEACAM1, to which most Opa proteins bind, was lower, and a small number of high-frequency haplotypes were detected. Dose-dependent associations of three CEACAM haplotypes with meningococcal disease were observed, with the effect of carrying these haplotypes amplified in homozygous individuals. Two haplotypes were protective while one haplotype in CEACAM6 was associated with a twofold increase in disease susceptibility. These data imply that human CEACAM may be one determinant of human susceptibility to meningococcal disease.
has issue date	2007-10-25(xsd:dateTime)
bibo:doi	10.1038/sj.gene.6364442
bibo:pmid	17960155
has license	no-cc
sha1sum (hex)	6364ca0ffa46d82fceaf412b092e78935cb1268b
schema:url	https://doi.org/10.1038/sj.gene.6364442
resource representing a document's title	Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease
has PubMed Central identifier	PMC7094765
has PubMed identifier	17960155
schema:publication	Genes Immun
resource representing a document's body	covid:6364ca0ffa46d82fceaf412b092e78935cb1268b#body_text
is schema:about of	named entity 'GENES' named entity 'SUSCEPTIBILITY' named entity 'OPACITY' named entity 'CARRYING' named entity 'SITES' named entity 'HOSTS' named entity 'HIGH' named entity 'DETERMINE' named entity 'ADHESION' named entity '384' named entity 'SMALL' named entity 'DIVERSITY' named entity 'CEACAM1' named entity 'DISTRIBUTIONS' named entity 'BACTERIAL INFECTION' named entity 'CAUSED BY' named entity 'THESE' named entity 'DETECTED' named entity 'CEACAM6' named entity 'PROTEINS' named entity 'ACQUISITION' named entity 'BUT' named entity 'SAMPLES' named entity '190' named entity 'DATA' named entity 'HOMOZYGOUS' named entity 'DIVERSITY' named entity 'EFFECTS' named entity 'ASSOCIATED WITH' named entity 'POLYMORPHISMS' named entity 'INDIVIDUALS' named entity 'DETERMINANT' named entity 'LINKAGE DISEQUILIBRIUM' named entity 'DISEASE' named entity 'RELATIONSHIPS' named entity 'GENES' named entity 'GENOTYPES' named entity 'EFFECT' named entity 'STAGE' named entity 'NEISSERIA MENINGITIDIS' named entity 'OBSERVED' named entity 'AMPLIFIED' named entity 'HUMAN' named entity 'ASSOCIATIONS' named entity 'COMPARED' named entity 'MAY BE' named entity 'CELL ADHESION MOLECULE' named entity 'HUMAN' named entity 'ADHESIN' named entity 'MENINGOCOCCAL DISEASE' named entity 'SUSCEPTIBILITY' named entity 'FREQUENCY' named entity 'MENINGOCOCCAL' named entity 'INCREASE' named entity 'AIM' named entity 'BIND' named entity 'MENINGOCOCCAL DISEASE' named entity 'GENETIC DIVERSITY' named entity 'CASE' named entity 'LOWER' named entity 'WHY' named entity 'POLYMORPHIC' named entity 'DOSE-DEPENDENT' named entity 'OPA' named entity 'HAPLOTYPES' named entity 'GLOBALLY' named entity 'IMPORTANT' named entity 'DISEASE SUSCEPTIBILITY' named entity 'OUR' named entity 'PATHOGENESIS' named entity 'EMBRYONIC ANTIGEN'

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