About: Analysis of the humoral immune responses among cynomolgus macaque naturally infected with Reston virus during the 1996 outbreak in the Philippines

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About: Analysis of the humoral immune responses among cynomolgus macaque naturally infected with Reston virus during the 1996 outbreak in the Philippines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Analysis of the humoral immune responses among cynomolgus macaque naturally infected with Reston virus during the 1996 outbreak in the Philippines
Creator	Mizutani, Tetsuya Ikegami, Tetsuro Akashi, Hiroomi Fukushi, Shuetsu Iizuka, Itoe Ishii, Yoshiyuki Kyuwa, Shigeru Morikawa, Shigeru Nagata, Noriyo Saijo, Masayuki Sayama, Yusuke Taniguchi, Satoshi Watanabe, Shumpei Yoshikawa, Yasuhiro Miranda, Mary
Source	Medline; PMC
abstract	BACKGROUND: Ebolaviruses induce lethal viral hemorrhagic fevers (VHFs) in humans and non-human primates, with the exceptions of Reston virus (RESTV), which is not pathogenic for humans. In human VHF cases, extensive analyses of the humoral immune responses in survivors and non-survivors have shown that the IgG responses to nucleoprotein (NP) and other viral proteins are associated with asymptomatic and survival outcomes, and that the neutralizing antibody responses targeting ebolaviruses glycoprotein (GP(1,2)) are the major indicator of protective immunity. On the other hand, the immune responses in non-human primates, especially naturally infected ones, have not yet been elucidated in detail, and the significance of the antibody responses against NP and GP(1,2) in RESTV-infected cynomolgus macaques is still unclear. In this study, we analyzed the humoral immune responses of cynomolgus macaque by using serum specimens obtained from the RESTV epizootic in 1996 in the Philippines to expand our knowledge on the immune responses in naturally RESTV-infected non-human primates. RESULTS: The antibody responses were analyzed using IgG-ELISA, an indirect immunofluorescent antibody assay (IFA), and a pseudotyped VSV-based neutralizing (NT) assay. Antigen-capture (Ag)-ELISA was also performed to detect viral antigens in the serum specimens. We found that the anti-GP(1,2) responses, but not the anti-NP responses, closely were correlated with the neutralization responses, as well as the clearance of viremia in the sera of the RESTV-infected cynomolgus macaques. Additionally, by analyzing the cytokine/chemokine concentrations of these serum specimens, we found high concentrations of proinflammatory cytokines/chemokines, such as IFNγ, IL8, IL-12, and MIP1α, in the convalescent phase sera. CONCLUSIONS: These results imply that both the antibody response to GP(1,2) and the proinflammatory innate responses play significant roles in the recovery from RESTV infection in cynomolgus macaques.
has issue date	2012-10-11(xsd:dateTime)
bibo:doi	10.1186/1746-6148-8-189
bibo:pmid	23057674
has license	cc-by
sha1sum (hex)	633715b2acfa849d613285b7a01531072c2b3422
schema:url	https://doi.org/10.1186/1746-6148-8-189
resource representing a document's title	Analysis of the humoral immune responses among cynomolgus macaque naturally infected with Reston virus during the 1996 outbreak in the Philippines
has PubMed Central identifier	PMC3528628
has PubMed identifier	23057674
schema:publication	BMC Vet Res
resource representing a document's body	covid:633715b2acfa849d613285b7a01531072c2b3422#body_text
is schema:about of	named entity 'antibody' named entity 'serum' named entity 'The' named entity 'infected' named entity 'Reston virus' named entity 'NEUTRALIZATION' named entity 'VIRUS' named entity 'CAPTURE' named entity 'OBTAINED' named entity 'NEUTRALIZING ANTIBODY' named entity 'PRIMATES' named entity 'IL-12' named entity 'BASED' named entity 'VIREMIA' named entity 'IGG' named entity 'SPECIMENS' named entity 'TARGETING' named entity 'IFN' named entity 'VIRAL ANTIGENS' named entity 'SURVIVORS' named entity 'IMMUNE RESPONSES' named entity 'HUMANS' named entity 'CYNOMOLGUS MACAQUE' named entity 'ANALYZING' named entity 'GLYCOPROTEIN' named entity 'EXTENSIVE' named entity 'INDUCE' named entity 'THESE' named entity 'ANALYZED' named entity 'PATHOGENIC' named entity 'CORRELATED' named entity 'SERUM' named entity 'INDIRECT' named entity 'ELISA' named entity 'BUT' named entity 'ASYMPTOMATIC' named entity 'EPIZOOTIC' named entity 'ASSAY' named entity 'THE PHILIPPINES' named entity 'PERFORMED' named entity 'ASSOCIATED WITH' named entity 'ANTIBODY' named entity 'SIGNIFICANCE' named entity 'CLEARANCE' named entity 'STUDY' named entity 'PROTECTIVE IMMUNITY' named entity 'CYTOKINE' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'RESTV' named entity 'HIGH' named entity 'MAJOR' named entity 'OUTCOMES' named entity 'VSV' named entity 'NUCLEOPROTEIN' named entity 'CYNOMOLGUS MACAQUE' named entity 'CASES' named entity 'IMMUNE RESPONSES' named entity 'INFECTED' named entity 'ANALYSIS' named entity 'OUTBREAK' named entity 'KNOWLEDGE' named entity 'RESTON' named entity 'LETHAL' named entity 'HAVE' named entity 'FOUND' named entity 'CONVALESCENT PHASE' named entity 'VIRUS'

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