About: In Vitro and in Vivo Studies of the Inhibitory Effects of Emodin Isolated from Polygonum cuspidatum on Coxsakievirus B(4)

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About: In Vitro and in Vivo Studies of the Inhibitory Effects of Emodin Isolated from Polygonum cuspidatum on Coxsakievirus B(4) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	In Vitro and in Vivo Studies of the Inhibitory Effects of Emodin Isolated from Polygonum cuspidatum on Coxsakievirus B(4)
Creator	Hou, Wei Wei, Fei Xiao, Hong Xiong, Hai-Rong Yang, Zhan-Qiu Luo, Fan Chen, Liang-Jun Liu, Yuan-Yuan Liu, Zhao
Source	Medline; PMC
abstract	The lack of effective therapeutics for Coxsackievirus B(4) (CVB(4)) infection underscores the importance of finding novel antiviral compounds. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is one of the natural anthraquinone derivatives obtained from the root and rhizome of Polygonum cuspidatum. In the present study, the possibility of using emodin as a potential antiviral to treat CVB(4) infection was explored in vitro and in mice. Emodin reduced CVB(4) entry and replication on Hep-2 cells in a concentration- and time-dependent manner, with a 50% effective concentration (EC(50)) of 12.06 μM and selectivity index (SI) of 5.08, respectively. The inhibitory effect of emodin for CVB(4) entry and replication was further confirmed by a quantitative real time PCR (qPCR) assay. The results further showed that the mice orally treated with different dosages of emodin displayed a dose dependent increase of survival rate, body weight and prolonged mean time of death (MTD), accompanied by significantly decreased myocardial virus titers and pathologic scores/lesions. Moreover, emodin could inhibit CVB(4)-induced apoptosis in vitro and in vivo. Our results indicated that emodin could be used as potential antiviral in the post-exposure prophylaxis for CVB(4) infection.
has issue date	2013-09-25(xsd:dateTime)
bibo:doi	10.3390/molecules181011842
bibo:pmid	24071990
has license	cc-by
sha1sum (hex)	62f01258c5feeb75f8e3e3d628f5094b4b20b8c8
schema:url	https://doi.org/10.3390/molecules181011842
resource representing a document's title	In Vitro and in Vivo Studies of the Inhibitory Effects of Emodin Isolated from Polygonum cuspidatum on Coxsakievirus B(4)
has PubMed Central identifier	PMC6269740
has PubMed identifier	24071990
schema:publication	Molecules
resource representing a document's body	covid:62f01258c5feeb75f8e3e3d628f5094b4b20b8c8#body_text
is schema:about of	named entity 'molecules' named entity 'B 4' named entity 'IN VIVO STUDIES' covid:arg/62f01258c5feeb75f8e3e3d628f5094b4b20b8c8 named entity 'MOLECULES' named entity 'RHIZOME' named entity 'POST-EXPOSURE PROPHYLAXIS' named entity 'INHIBITORY EFFECT' named entity 'QUANTITATIVE REAL TIME PCR' named entity 'POLYGONUM CUSPIDATUM' named entity 'DEPENDENT' named entity 'REPLICATION' named entity 'NOVEL' named entity '50%' named entity 'EFFECTIVE' named entity 'ANTIVIRAL' named entity 'CELLS' named entity 'INCREASE' named entity 'ISOLATED' named entity 'INDEX' named entity 'RESULTS' named entity 'THERAPEUTICS' named entity 'DOSAGES' named entity 'INFECTION' named entity 'BCM' named entity 'TREATED WITH' named entity 'DECREASED' named entity 'POTENTIAL' named entity 'MYOCARDIAL' named entity 'CONFIRMED BY' named entity 'INHIBITORY' named entity 'EFFECTS' named entity 'ORALLY' named entity 'DIFFERENT' named entity 'APOPTOSIS' named entity 'COXSACKIEVIRUS B' named entity 'SELECTIVITY' named entity 'TIME OF DEATH' named entity 'IN VITRO' named entity 'EMODIN' named entity 'MICE' named entity 'ASSAY' named entity 'CVB' named entity 'TRIHYDROXY' named entity 'LACK' named entity 'PRESENT' named entity 'IN VITRO' named entity 'TIME' named entity 'OUR' named entity 'ANTHRAQUINONE' named entity 'PATHOLOGIC' named entity 'IN VIVO' named entity 'REDUCED' named entity 'INDICATED' named entity 'OBTAINED' named entity 'ONE OF' named entity 'TREAT' named entity 'USING' named entity 'DISPLAYED' named entity 'CONCENTRATION' named entity 'POLYGONUM CUSPIDATUM' named entity 'VIRUS' named entity 'HEP-2' named entity 'FINDING' named entity 'INDUCED' named entity 'PROLONGED' named entity 'SURVIVAL RATE' named entity 'POSSIBILITY OF' named entity 'ENTRY' named entity 'USED' named entity 'STUDY' named entity 'DOSE' named entity 'BODY WEIGHT'

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