About: Type 1 Interferons and NK Cells Limit Murine Cytomegalovirus Escape from the Lymph Node Subcapsular Sinus

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About: Type 1 Interferons and NK Cells Limit Murine Cytomegalovirus Escape from the Lymph Node Subcapsular Sinus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Type 1 Interferons and NK Cells Limit Murine Cytomegalovirus Escape from the Lymph Node Subcapsular Sinus
Creator	Bruce, Kimberley Lawler, Clara Cardin, Rhonda Davis-Poynter, Nicholas Farrell, Helen Stevenson, Philip
Source	Medline; PMC
abstract	Cytomegaloviruses (CMVs) establish chronic, systemic infections. Peripheral infection spreads via lymph nodes, which are also a focus of host defence. Thus, this is a point at which systemic infection spread might be restricted. Subcapsular sinus macrophages (SSM) captured murine CMV (MCMV) from the afferent lymph and poorly supported its replication. Blocking the type I interferon (IFN-I) receptor (IFNAR) increased MCMV infection of SSM and of the fibroblastic reticular cells (FRC) lining the subcapsular sinus, and accelerated viral spread to the spleen. Little splenic virus derived from SSM, arguing that they mainly induce an anti-viral state in the otherwise susceptible FRC. NK cells also limited infection, killing infected FRC and causing tissue damage. They acted independently of IFN-I, as IFNAR blockade increased NK cell recruitment, and NK cell depletion increased infection in IFNAR-blocked mice. Thus SSM restricted MCMV infection primarily though IFN-I, with NK cells providing a second line of defence. The capacity of innate immunity to restrict MCMV escape from the subcapsular sinus suggested that enhancing its recruitment might improve infection control.
has issue date	2016-12-07(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1006069
bibo:pmid	27926941
has license	cc0
sha1sum (hex)	62af9e71368a90bd8fce0347e90527e3e4da3800
schema:url	https://doi.org/10.1371/journal.ppat.1006069
resource representing a document's title	Type 1 Interferons and NK Cells Limit Murine Cytomegalovirus Escape from the Lymph Node Subcapsular Sinus
has PubMed Central identifier	PMC5142805
has PubMed identifier	27926941
schema:publication	PLoS Pathog
resource representing a document's body	covid:62af9e71368a90bd8fce0347e90527e3e4da3800#body_text
is schema:about of	named entity 'ESCAPE' named entity 'LIMIT' named entity 'infection' named entity 'innate' named entity 'MCMV' named entity 'chronic' named entity 'INTERFERONS' named entity 'INDUCE' named entity 'SPLEEN' named entity 'SUSCEPTIBLE' named entity 'KILLING' named entity 'IFN' named entity 'BLOCKADE' named entity 'VIRUS' named entity 'LYMPH NODES' covid:arg/62af9e71368a90bd8fce0347e90527e3e4da3800 named entity 'SYSTEMIC INFECTION' named entity 'INFECTION CONTROL' named entity 'CAPACITY' named entity 'MACROPHAGES' named entity 'MCMV' named entity 'CHRONIC' named entity 'POORLY' named entity 'IS A' named entity 'MURINE CYTOMEGALOVIRUS' named entity 'TYPE 1' named entity 'FOCUS' named entity 'ESTABLISH' named entity 'PERIPHERAL' named entity 'CMV' named entity 'LYMPH NODE SUBCAPSULAR SINUS' named entity 'AFFERENT' named entity 'DEPLETION' named entity 'LYMPH' named entity 'INNATE IMMUNITY' named entity 'MICE' named entity 'SECOND' named entity 'STATE' named entity 'INTERFERON ' named entity 'TISSUE DAMAGE' named entity 'ITS' named entity 'SSM' named entity 'SUPPORTED' named entity 'LINE' named entity 'PROVIDING' named entity 'SYSTEMIC INFECTIONS' named entity 'IFNAR' named entity 'MURINE' named entity 'BLOCKING' named entity 'RETICULAR CELLS' named entity 'INFECTED' named entity 'LINING' named entity 'INFECTION' named entity 'REPLICATION' named entity 'ESCAPE' named entity 'SPREADS' named entity 'CAUSING' named entity 'RECEPTOR' named entity 'RECRUITMENT' named entity 'INCREASED' named entity 'MIGHT BE' named entity 'ENHANCING' named entity 'FRC' named entity 'LITTLE' named entity 'TYPE I INTERFERON' named entity 'ACCELERATED' named entity 'HOST' named entity 'NK CELLS' named entity 'SPREAD' named entity 'SUBCAPSULAR SINUS' named entity 'LIMITED' named entity 'NK CELLS' named entity 'SPLENIC' named entity 'A POINT' named entity 'BLOCKED' named entity 'DERIVED'

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