About: Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity
Creator	Honko, Anna Griffiths, Anthony Downs, Sierra Fang, Ronnie Gao, Weiwei Gong, Hua Zhang, Liangfang Zhang, Qiangzhe Zhou, Jiarong Henao Vasquez, Jhonatan
Source	Medline; PMC
abstract	[Image: see text] We report cellular nanosponges as an effective medical countermeasure to the SARS-CoV-2 virus. Two types of cellular nanosponges are made of the plasma membranes derived from human lung epithelial type II cells or human macrophages. These nanosponges display the same protein receptors, both identified and unidentified, required by SARS-CoV-2 for cellular entry. It is shown that, following incubation with the nanosponges, SARS-CoV-2 is neutralized and unable to infect cells. Crucially, the nanosponge platform is agnostic to viral mutations and potentially viral species, as well. As long as the target of the virus remains the identified host cell, the nanosponges will be able to neutralize the virus.
has issue date	2020-06-17(xsd:dateTime)
bibo:doi	10.1021/acs.nanolett.0c02278
bibo:pmid	32551679
has license	no-cc
sha1sum (hex)	629cfa3db435d3e124dfd174903632c80d74da84
schema:url	https://doi.org/10.1021/acs.nanolett.0c02278
resource representing a document's title	Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity
has PubMed Central identifier	PMC7301960
has PubMed identifier	32551679
schema:publication	Nano Lett
resource representing a document's body	covid:629cfa3db435d3e124dfd174903632c80d74da84#body_text
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