About: A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters

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About: A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters
Creator	Letko, Michael Feldmann, Friederike Bushmaker, Trenton Lambe, Teresa Fischer, Robert Scott, Dana Haddock, Elaine Sebastian, Sarah Rissanen, Ilona Avanzato, Victoria Bowden Id, Thomas Gilbert Id, Sarah Id, Vincent Lacasse, Rachel Van Doremalen Id, Neeltje
Source	Medline; PMC
abstract	Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals exist. Here, we investigated the efficacy of ChAdOx1 NiV(B), a simian adenovirus-based vaccine encoding NiV glycoprotein (G) Bangladesh, in Syrian hamsters. Prime-only as well as prime-boost vaccination resulted in uniform protection against a lethal challenge with NiV Bangladesh: all animals survived challenge and we were unable to find infectious virus either in oral swabs, lung or brain tissue. Furthermore, no pathological lung damage was observed. A single-dose of ChAdOx1 NiV(B) also prevented disease and lethality from heterologous challenge with NiV Malaysia. While we were unable to detect infectious virus in swabs or tissue of animals challenged with the heterologous strain, a very limited amount of viral RNA could be found in lung tissue by in situ hybridization. A single dose of ChAdOx1 NiV(B) also provided partial protection against Hendra virus and passive transfer of antibodies elicited by ChAdOx1 NiV(B) vaccination partially protected Syrian hamsters against NiV Bangladesh. From these data, we conclude that ChAdOx1 NiV(B) is a suitable candidate for further NiV vaccine pre-clinical development.
has issue date	2019-06-06(xsd:dateTime)
bibo:doi	10.1371/journal.pntd.0007462
bibo:pmid	31170144
has license	cc0
sha1sum (hex)	6276adaeca8fcd42c9565718ac6bbdc4f97aa10f
schema:url	https://doi.org/10.1371/journal.pntd.0007462
resource representing a document's title	A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters
has PubMed Central identifier	PMC6581282
has PubMed identifier	31170144
schema:publication	PLoS Negl Trop Dis
resource representing a document's body	covid:6276adaeca8fcd42c9565718ac6bbdc4f97aa10f#body_text
is schema:about of	named entity 'VACCINE' named entity 'PROVIDES' named entity 'Hendra virus' named entity 'heterologous' named entity 'RNA' named entity 'SYRIAN GOLDEN HAMSTERS' named entity 'LETHALITY' named entity 'BASED' named entity 'CONCLUDE' named entity 'EITHER' named entity 'SIMIAN ADENOVIRUS' named entity 'SINGLE' named entity 'GLYCOPROTEIN' named entity 'HETEROLOGOUS' named entity 'INVESTIGATED' named entity '28G' named entity 'IS A' named entity 'PROVIDED' named entity 'VACCINE' named entity 'NIPAH VIRUS' named entity 'PATHOGENIC' named entity 'EXIST' named entity 'LETHAL' named entity 'VIRUS' named entity 'OUTBREAKS' named entity 'DISEASE' named entity 'ENCODING' named entity 'BANGLADESH' named entity 'SWABS' named entity 'LICENSED VACCINE' named entity 'SUITABLE' named entity 'OBSERVED' named entity 'BANGLADESH' named entity 'MALAYSIA' named entity 'DOSE' named entity 'VECTORED' named entity 'COMPLETE' named entity 'LUNG TISSUE' named entity 'CANDIDATE' named entity 'HIGHLY' named entity 'CAUSES' named entity 'PROTECTION' named entity 'THESE' named entity 'PATHOLOGICAL' named entity 'MALAYSIA' named entity 'PARTIALLY' named entity 'PARTIAL' named entity 'HENDRA VIRUS' named entity 'PASSIVE' named entity 'VIRAL RNA' named entity 'HERE' named entity 'SINGLE' named entity 'CHALLENGE' named entity 'DAMAGE' named entity 'ELICITED BY' named entity 'ANTIBODIES' named entity 'PRIME' named entity 'SOUTH EAST ASIA' named entity 'IN SITU HYBRIDIZATION' named entity 'APPROVED' named entity 'BOOST VACCINATION' named entity 'OX1' named entity 'TRANSFER' named entity 'DOSE' named entity 'COULD BE' named entity 'ANIMALS' named entity 'PRE-CLINICAL'

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