About: Structural characterization of Mumps virus fusion protein core

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Structural characterization of Mumps virus fusion protein core
Creator	Rao, Zihe Lou, Zhiyong Tien, Po Gao, George Zhu, Jieqing Hu, Xuebo Liu, Yueyong Qiu, Bingsheng Xu, Yanhui
source	Elsevier; Medline; PMC
abstract	Abstract The fusion proteins of enveloped viruses mediating the fusion between the viral and cellular membranes comprise two discontinuous heptad repeat (HR) domains located at the ectodomain of the enveloped glycoproteins. The crystal structure of the fusion protein core of Mumps virus (MuV) was determined at 2.2Å resolution. The complex is a six-helix bundle in which three HR1 peptides form a central highly hydrophobic coiled-coil and three HR2 peptides pack against the hydrophobic grooves on the surface of central coiled-coil in an oblique antiparallel manner. Fusion core of MuV, like those of simian virus 5 and human respiratory syncytium virus, forms typical 3-4-4-4-3 spacing. The similar charecterization in HR1 regions, as well as the existence of O–X–O motif in extended regions of HR2 helix, suggests a basic rule for the formation of the fusion core of viral fusion proteins.
has issue date	2006-09-29(xsd:dateTime)
bibo:doi	10.1016/j.bbrc.2006.07.168
bibo:pmid	16904649
has license	els-covid
sha1sum (hex)	625a995854cfd1ade5f738008617e1176ac21615
schema:url	https://doi.org/10.1016/j.bbrc.2006.07.168
resource representing a document's title	Structural characterization of Mumps virus fusion protein core
has PubMed Central identifier	PMC7092830
has PubMed identifier	16904649
schema:publication	Biochemical and Biophysical Research Communications
resource representing a document's body	covid:625a995854cfd1ade5f738008617e1176ac21615#body_text
is schema:about of	named entity 'highly' named entity 'spacing' named entity 'peptides' named entity 'CRYSTAL STRUCTURE' named entity 'CORE' named entity 'CELLULAR' named entity 'MEDIATING' named entity 'HR2' named entity 'PROTEIN ' named entity 'HUMAN' named entity 'DETERMINED' named entity 'VIRAL FUSION PROTEINS' named entity 'FORMATION' named entity 'REPEAT' named entity 'SPACING' named entity 'DISCONTINUOUS' named entity 'ECTODOMAIN' named entity 'FORMS' named entity 'BUNDLE' named entity 'SIMIAN VIRUS 5' named entity 'SIMILAR' named entity 'TYPICAL' named entity 'VIRUSES' named entity 'FORM' named entity 'STRUCTURAL CHARACTERIZATION' named entity 'MUMPS VIRUS FUSION PROTEIN' named entity 'MOTIF' named entity 'RULE' named entity '3-4' named entity 'HR1' named entity 'CENTRAL' named entity 'MEMBRANES' named entity 'PROTEINS' named entity 'HIGHLY' named entity 'VIRUS' named entity 'FUSION PROTEIN' named entity 'PACK' named entity 'COILED-COIL' named entity 'PROTEIN ' named entity 'CORE' named entity 'RESPIRATORY' named entity 'IS A' named entity 'COMPLEX' named entity 'LIKE' named entity 'BASIC' named entity 'GROOVES' named entity 'GLYCOPROTEINS' named entity 'MUV' named entity 'HYDROPHOBIC' named entity 'SYNCYTIUM' named entity 'SURFACE' named entity 'PEPTIDES' named entity 'HELIX' named entity 'VIRAL AND' named entity 'FUSION' named entity 'COMPRISE' named entity 'EXTENDED' named entity 'REGIONS' named entity '2.2' named entity 'OBLIQUE' named entity 'RESOLUTION' named entity 'MUMPS VIRUS' covid:arg/625a995854cfd1ade5f738008617e1176ac21615 named entity 'typical' named entity 'coiled-coil' named entity 'grooves' named entity '4-4-4' named entity 'manner' named entity 'fusion protein' named entity 'fusion core' named entity 'virus' named entity 'hydrophobic' named entity 'Mumps virus'

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