About: P58(IPK): A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection

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About: P58(IPK): A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	P58(IPK): A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection
Creator	Peng, Xinxia Proll, Sean Carter, Victoria Perrone, Lucy Dyer, Matthew Fornek, Jamie Goodman, Alan Katze, Michael Knoblaugh, Sue Korth, Marcus Medigeshi, Guruprasad Nelson, Jay Tumpey, Terrence
Source	Medline; PMC
abstract	To support their replication, viruses take advantage of numerous cellular factors and processes. Recent large-scale screens have identified hundreds of such factors, yet little is known about how viruses exploit any of these. Influenza virus infection post-translationally activates P58(IPK), a cellular inhibitor of the interferon-induced, dsRNA-activated eIF2α kinase, PKR. Here, we report that infection of P58(IPK) knockout mice with influenza virus resulted in increased lung pathology, immune cell apoptosis, PKR activation, and mortality. Analysis of lung transcriptional profiles, including those induced by the reconstructed 1918 pandemic virus, revealed increased expression of genes associated with the cell death, immune, and inflammatory responses. These experiments represent the first use of a mammalian infection model to demonstrate the role of P58(IPK) in the antiviral response. Our results suggest that P58(IPK) represents a new class of molecule, a cellular inhibitor of the host defense (CIHD), as P58(IPK) is activated during virus infection to inhibit virus-induced apoptosis and inflammation to prolong host survival, even while prolonging viral replication.
has issue date	2009-05-22(xsd:dateTime)
bibo:doi	10.1371/journal.ppat.1000438
bibo:pmid	19461876
has license	cc0
sha1sum (hex)	61f80012b6b8ea03a65fe97eefc30480990b11be
schema:url	https://doi.org/10.1371/journal.ppat.1000438
resource representing a document's title	P58(IPK): A Novel “CIHD” Member of the Host Innate Defense Response against Pathogenic Virus Infection
has PubMed Central identifier	PMC2677460
has PubMed identifier	19461876
schema:publication	PLoS Pathog
resource representing a document's body	covid:61f80012b6b8ea03a65fe97eefc30480990b11be#body_text
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